UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (PA3646)

Identification
Name: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
Synonyms:
  • Protein firA
  • Rifampicin resistance protein
Gene Name: lpxD
Enzyme Class:
Biological Properties
General Function: Involved in transferase activity
Specific Function: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] = UDP-2,3-bis(3- hydroxytetradecanoyl)glucosamine + [acyl-carrier-protein]
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Acyl-carrier protein+(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] ↔ Thumb+(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]+Acyl-carrier protein
UDP-2,3-Bis(3-hydroxytetradecanoyl)glucosamine + Acyl-carrier protein + (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] ↔ UDP-3-O-(3-Hydroxytetradecanoyl)-D-glucosamine + (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] + Acyl-carrier protein
ReactionCard
SMPDB Reactions:
Thumb+(3R)-3-hydroxymyristoyl-[acp] → Thumb+a holo-[acyl-carrier protein]+Thumb
UDP-3-O-(3-Hydroxytetradecanoyl)-D-glucosamine + (3R)-3-hydroxymyristoyl-[acp] → Hydrogen ion + a holo-[acyl-carrier protein] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine
ReactionCard
PseudoCyc/BioCyc Reactions:
(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]+Thumb → acyl carrier protein+Thumb+Thumb
(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] + UDP-3-O-(3-Hydroxytetradecanoyl)-D-glucosamine → acyl carrier protein + Hydrogen ion + UDP-2,3-Bis(3-hydroxytetradecanoyl)glucosamine
ReactionCard
Thumb+Acyl-carrier protein+(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] ↔ Thumb+(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]+Acyl-carrier protein
UDP-2,3-Bis(3-hydroxytetradecanoyl)glucosamine + Acyl-carrier protein + (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] ↔ UDP-3-O-(3-Hydroxytetradecanoyl)-D-glucosamine + (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] + Acyl-carrier protein
ReactionCard
Thumb+(3R)-3-hydroxymyristoyl-[acp] → Thumb+a holo-[acyl-carrier protein]+Thumb
UDP-3-O-(3-Hydroxytetradecanoyl)-D-glucosamine + (3R)-3-hydroxymyristoyl-[acp] → Hydrogen ion + a holo-[acyl-carrier protein] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine
ReactionCard
Complex Reactions:
(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]+Thumb → acyl carrier protein+Thumb+Thumb
(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] + UDP-3-O-(3-Hydroxytetradecanoyl)-D-glucosamine → acyl carrier protein + Hydrogen ion + UDP-2,3-Bis(3-hydroxytetradecanoyl)glucosamine
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0018883-Hydroxymyristic acidMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001047UDP-2,3-Bis(3-hydroxytetradecanoyl)glucosamineMetaboCard
PAMDB003524UDP-2,3-bis(O-(3R)-3-Hydroxymyristoyl)-alpha-D-glucosamineMetaboCard
PAMDB006333UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamineMetaboCard
PAMDB001696UDP-3-O-(3-Hydroxytetradecanoyl)-D-glucosamineMetaboCard
GO Classification:
Function
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
Process
lipid A biosynthetic process
metabolic process
organophosphate metabolic process
phospholipid biosynthetic process
phospholipid metabolic process
Gene Properties
Locus tag: PA3646
Strand: -
Entrez Gene ID: 880525
Accession: NP_252336.1
GI: 15598842
Sequence start: 4083444
Sequence End: 4084505
Sequence Length: 1061
Gene Sequence: 
>PA3646
ATGATGAGTACCTTGTCCTACACCCTGGGCCAGCTGGCCGCGCATGTCGGCGCGGAAGTCCGTGGCGACGCGGACCTGCCAATCCAGGGCCTGGCGACCTTGCAGGAGGCCGGACCGGCTCAGCTGAGCTTCCTGGCCAACCCGCAGTATCGCAAGTACCTGCCCGAAAGCCGTGCCGGCGCCGTCCTGCTGACGGCTGCCGACGCCGACGGGTTCGCCGGTACCGCGCTGGTGGTGGCCAACCCCTACCTGGCCTATGCCAGCCTGTCGCACCTGTTCGATCGCAAACCGAAGGCGGCCGCCGGTATCCATCCTACCGCCATCGTCGCGGCGGACGCCGAGGTCGATCCGAGCGCCAGCGTCGGCGCCTATGCGGTGATCGAGAGTGGCGCCCGCATCGGCGCTGGCGTCAGCATCGGCGCGCACTGCGTGATCGGAGCCCGTAGCGTGATCGGCGAAGGCGGCTGGCTGGCGCCGCGAGTCACGCTCTACCACGACGTCACCATCGGCGCGCGGGTGAGTATCCAGTCGGGCGCGGTGATCGGCGGCGAAGGTTTCGGTTTCGCCAACGAGAAGGGCGTCTGGCAGAAGATCGCCCAGATCGGCGGGGTGACCATCGGTGACGACGTCGAGATCGGCGCGAACACCACCATCGACCGTGGAGCACTGTCCGATACGCTGATCGGCAACGGTGTGAAGCTGGACAACCAGATCATGATCGCGCACAACGTGCAGATCGGCGATCATACCGCCATGGCCGCTTGCGTCGGCATTTCCGGCAGCGCCAAGATCGGCAGGCATTGCATGCTCGCCGGCGGCGTTGGCCTGGTCGGCCATATCGAGATCTGCGACAACGTTTTCGTGACCGGCATGACCATGGTGACCCGCTCGATCACCGAGCCGGGATCGTATTCCTCCGGTACCGCCATGCAACCGGCGGCCGAATGGAAAAAAAGCGCCGCGCGCATTCGTCAACTGGACGACATGGCGCGTCGACTTCAGCAGCTGGAAAAACGCCTGGCTGCCGTGACCTCAAGCGGTGACGCTTCATCTGATGCGTAA
Protein Properties
Protein Residues: 353
Protein Molecular Weight: 36.2 kDa
Protein Theoretical pI: 6.23
Hydropathicity (GRAVY score): 0.187
Charge at pH 7 (predicted): -3.96
Protein Sequence: 
>PA3646
MMSTLSYTLGQLAAHVGAEVRGDADLPIQGLATLQEAGPAQLSFLANPQYRKYLPESRAGAVLLTAADADGFAGTALVVANPYLAYASLSHLFDRKPKAAAGIHPTAIVAADAEVDPSASVGAYAVIESGARIGAGVSIGAHCVIGARSVIGEGGWLAPRVTLYHDVTIGARVSIQSGAVIGGEGFGFANEKGVWQKIAQIGGVTIGDDVEIGANTTIDRGALSDTLIGNGVKLDNQIMIAHNVQIGDHTAMAACVGISGSAKIGRHCMLAGGVGLVGHIEICDNVFVTGMTMVTRSITEPGSYSSGTAMQPAAEWKKSAARIRQLDDMARRLQQLEKRLAAVTSSGDASSDA
References
External Links:
Resource Link
Genome ID: PA3646
Entrez Gene ID: 880525
NCBI Protein ID: 15598842
General Reference: PaperBLAST - Find papers about PA3646 and its homologs