| Identification |
| Name: |
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase |
| Synonyms: |
- UDP-N-acetylglucosamine acyltransferase
|
| Gene Name: |
lpxA |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in transferase activity |
| Specific Function: |
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell |
| Cellular Location: |
Cytoplasm |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] | + |  | + | (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] | ↔ | Acyl-carrier protein | + |  | + | Acyl-carrier protein |
| |
|
| SMPDB Reactions: |
|
| + | (3R)-3-hydroxymyristoyl-[acp] | → | a holo-[acyl-carrier protein] | + |  |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] | + | | + | (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] | ↔ | Acyl-carrier protein | + | | + | Acyl-carrier protein |
| | |
(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] | + | | → | [acyl-carrier-protein] | + | |
| | |
| + | (3R)-3-hydroxymyristoyl-[acp] | → | a holo-[acyl-carrier protein] | + | |
| | | a (3 R)-3-hydroxymyristoyl-[acp] + UDP- N-acetyl-α-D-glucosamine → a holo-[acyl-carrier protein] + UDP-3- O-[(3 R)-3-hydroxymyristoyl]- N-acetyl-α-D-glucosamine ReactionCard |
|
| Complex Reactions: |
|
(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] | + | | ↔ | acyl carrier protein | + | |
| | |
(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] | + | | → | [acyl-carrier-protein] | + | |
| |
|
| Transports: |
Not Available |
| Metabolites: |
| PAMDB ID | Name | View |
|---|
| PAMDB000644 | UDP-3-O-(3-Hydroxymyristoyl)-N-acetylglucosamine | MetaboCard | | PAMDB006332 | UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-α-D-glucosamine | MetaboCard | | PAMDB000120 | Uridine diphosphate-N-acetylglucosamine | MetaboCard |
|
| GO Classification: |
| Function |
|---|
| acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity | | acyltransferase activity | | catalytic activity | | O-acyltransferase activity | | transferase activity | | transferase activity, transferring acyl groups | | transferase activity, transferring acyl groups other than amino-acyl groups | | Process |
|---|
| lipid biosynthetic process | | lipid metabolic process | | metabolic process | | primary metabolic process |
|
| Gene Properties |
| Locus tag: |
PA3644 |
| Strand: |
- |
| Entrez Gene ID: |
880493 |
| Accession: |
NP_252334.1 |
| GI: |
15598840 |
| Sequence start: |
4082185 |
| Sequence End: |
4082961 |
| Sequence Length: |
776 |
| Gene Sequence: |
>PA3644
ATGAGTTTGATCGATCCTCGCGCCATCATCGATCCGAGCGCCAGGCTGGCGGCTGACGTCCAGGTGGGCCCGTGGTCCATCGTCGGGGCGGAAGTGGAGATCGGTGAAGGGACGGTGATCGGTCCGCACGTGGTGCTCAAGGGCCCCACGAAGATCGGCAAGCACAACCGCATCTACCAGTTTTCCAGCGTCGGCGAGGATACTCCCGACCTGAAATACAAGGGCGAGCCGACGCGCCTGGTGATCGGTGACCACAACGTGATCCGCGAAGGCGTGACCATCCATCGCGGAACCGTCCAGGATCGCGCGGAAACCACCATTGGCGACCACAACCTGATCATGGCCTATGCGCACATCGGCCATGACAGCGTGATCGGCAACCATTGCATCCTGGTGAACAACACGGCGCTGGCCGGGCATGTCCACGTGGACGACTGGGCGATCCTGTCCGGCTACACCCTGGTGCACCAGTACTGCCGGATCGGCGCGCACAGCTTTTCCGGCATGGGCAGCGCCATCGGCAAGGACGTCCCGGCCTACGTGACGGTCTTCGGCAACCCGGCCGAAGCCCGCAGCATGAACTTCGAAGGCATGCGTCGGCGCGGCTTCAGCAGCGAGGCCATCCATGCCCTGCGGCGTGCCTACAAGGTGGTCTATCGCCAGGGACATACCGTCGAGGAAGCCCTGGCCGAGCTGGCCGAAAGCGCTGCCCAGTTCCCCGAGGTCGCGGTGTTCCGTGATTCCATCCAGAGCGCAACCCGCGGCATCACCCGCTGA |
| Protein Properties |
| Protein Residues: |
258 |
| Protein Molecular Weight: |
28 kDa |
| Protein Theoretical pI: |
7.05 |
| Hydropathicity (GRAVY score): |
-0.118 |
| Charge at pH 7 (predicted): |
0.3 |
| Protein Sequence: |
>PA3644
MSLIDPRAIIDPSARLAADVQVGPWSIVGAEVEIGEGTVIGPHVVLKGPTKIGKHNRIYQFSSVGEDTPDLKYKGEPTRLVIGDHNVIREGVTIHRGTVQDRAETTIGDHNLIMAYAHIGHDSVIGNHCILVNNTALAGHVHVDDWAILSGYTLVHQYCRIGAHSFSGMGSAIGKDVPAYVTVFGNPAEARSMNFEGMRRRGFSSEAIHALRRAYKVVYRQGHTVEEALAELAESAAQFPEVAVFRDSIQSATRGITR |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA3644 and its homologs
|
