3-isopropylmalate dehydratase small subunit (PA3120)

Identification
Name: 3-isopropylmalate dehydratase small subunit
Synonyms:
  • Alpha-IPM isomerase
  • IPMI
  • Isopropylmalate isomerase
Gene Name: leuD
Enzyme Class:
Biological Properties
General Function: Involved in 3-isopropylmalate dehydratase activity
Specific Function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb ↔ Thumb+Thumb
3-Isopropylmalate ↔ Isopropylmaleate + Water
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Thumb+Thumb ↔ Thumb
Isopropylmaleate + Water ↔ 2-Isopropylmalic acid
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(R)-2-Methylmalate ↔ Thumb+Thumb
(R)-2-Methylmalate ↔ Citraconic acid + Water
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Thumb+Thumb ↔ Thumb
Citraconic acid + Water ↔ D-Erythro-3-Methylmalate
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Thumb+Thumb+Thumb ↔ Thumb
3-Isopropylmalate + Isopropylmaleate + Water ↔ 2-Isopropylmalic acid
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SMPDB Reactions:
Thumb → Thumb+Thumb
2-Isopropylmalic acid → Water + Isopropylmaleate
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Thumb+Thumb → Thumb
Isopropylmaleate + Water → 3-Isopropylmalate
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Thumb+Thumb → Citramalic acid
Citraconic acid + Water → Citramalic acid
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PseudoCyc/BioCyc Reactions:
Thumb ↔ Thumb+Thumb
3-Isopropylmalate ↔ Isopropylmaleate + Water
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Complex Reactions:
Thumb → Thumb+Thumb
3-Isopropylmalate → Isopropylmaleate + Water
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Thumb+Thumb → Thumb
Isopropylmaleate + Water → 2-Isopropylmalic acid
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0001352-Isopropylmalic acidMetaboCard
PAMDB0006413-IsopropylmalateMetaboCard
PAMDB001792Citraconic acidMetaboCard
PAMDB000985D-Erythro-3-MethylmalateMetaboCard
PAMDB000832IsopropylmaleateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
3-isopropylmalate dehydratase complex
macromolecular complex
protein complex
Function
3-isopropylmalate dehydratase activity
carbon-oxygen lyase activity
catalytic activity
hydro-lyase activity
lyase activity
Process
branched chain family amino acid metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
leucine biosynthetic process
leucine metabolic process
metabolic process
Gene Properties
Locus tag: PA3120
Strand: -
Entrez Gene ID: 882818
Accession: NP_251810.1
GI: 15598316
Sequence start: 3502642
Sequence End: 3503280
Sequence Length: 638
Gene Sequence: 
>PA3120
ATGAAACCCTATACCCAGACGACCGGTCTCGTCGCTCCGCTGGATCGCGCCAACGTCGATACCGATCAGATCATTCCCAAGCAATTCCTCAAGTCGATCAAGCGCACCGGCTTCGGCCCCAACCTGTTCGACGAATGGCGCTACCTGGATGTCGGGCAGCCGGGACAGGACAACTCGAAGCGTCCGCTGAACCCGGACTTCGTCCTCAACCAGCCGCGCTACCAGGGCGCCAGCGTACTGCTGGCGCGGGAGAACTTCGGCTGCGGCTCGTCTCGCGAGCACGCGCCCTGGGCGCTGGACGAGTACGGTTTCCGCACGGTGATCGCACCGAGCTATGCCGACATCTTCTTCAACAACAGTTTCAAGAACGGCTTGCTGCCGATCATCCTGCCCGAGGCCGAGGTGGACGAACTGTTCCGCCAGGTCGAGGCGAACGAAGGCTACCAGTTGTCCATCGACCTGGCGGCGCAGACCGTTACCCGTCCTGATGGCAAGGTGCTGGGTTTCGAGGTCGACCCGTTCCGCAAGCATTGCCTGCTCAACGGCCTCGACGACATCGGCCTGACGCTGCAGGACGCCGATGCGATCCGTGCCTTCGAGGACGGCTACCGCCAGCAGCAGCCCTGGCTGTTCCGCTGA
Protein Properties
Protein Residues: 212
Protein Molecular Weight: 24 kDa
Protein Theoretical pI: 4.67
Hydropathicity (GRAVY score): -0.438
Charge at pH 7 (predicted): -6.58
Protein Sequence: 
>PA3120
MKPYTQTTGLVAPLDRANVDTDQIIPKQFLKSIKRTGFGPNLFDEWRYLDVGQPGQDNSKRPLNPDFVLNQPRYQGASVLLARENFGCGSSREHAPWALDEYGFRTVIAPSYADIFFNNSFKNGLLPIILPEAEVDELFRQVEANEGYQLSIDLAAQTVTRPDGKVLGFEVDPFRKHCLLNGLDDIGLTLQDADAIRAFEDGYRQQQPWLFR
References
External Links:
Resource Link
Genome ID: PA3120
Entrez Gene ID: 882818
NCBI Protein ID: 15598316
General Reference: PaperBLAST - Find papers about PA3120 and its homologs