| Identification |
| Name: |
Succinyl-diaminopimelate desuccinylase |
| Synonyms: |
- SDAP desuccinylase
- N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
|
| Gene Name: |
dapE |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in metallopeptidase activity |
| Specific Function: |
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls |
| Cellular Location: |
Cytoplasmic |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
| SMPDB Reactions: |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
Not Available |
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Function |
|---|
| binding | | catalytic activity | | hydrolase activity | | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | | metallopeptidase activity | | peptidase activity | | peptidase activity, acting on L-amino acid peptides | | protein binding | | succinyl-diaminopimelate desuccinylase activity | | Process |
|---|
| aspartate family amino acid metabolic process | | cellular amino acid and derivative metabolic process | | cellular amino acid metabolic process | | cellular metabolic process | | lysine biosynthetic process | | lysine biosynthetic process via diaminopimelate | | lysine metabolic process | | macromolecule metabolic process | | metabolic process | | protein metabolic process | | proteolysis |
|
| Gene Properties |
| Locus tag: |
PA1162 |
| Strand: |
- |
| Entrez Gene ID: |
877783 |
| Accession: |
NP_249853.1 |
| GI: |
15596359 |
| Sequence start: |
1259291 |
| Sequence End: |
1260442 |
| Sequence Length: |
1151 |
| Gene Sequence: |
>PA1162
ATGACCGCCTCTTCGCCGAGTCTCTCGCCGACCCTCGAACTCGCCTGCGAGTTGATCCGCCGCCCCTCCGTCACGCCGCTCGACGCCGACTGCCAGGCCCTGATGATGCGCCGCCTGGAAGCCGCCGGCTTCGCCCTGGAGCCGATGCGCATCGAGGAGGTGGACAACTTCTGGGCACGGCGCGGCGGCGACGGCCCGGTGCTGTGCTTCGCCGGGCACACCGACGTGGTCCCCACCGGCCCGCTGCAGGCCTGGCAGCACCAACCCTTCGACGCCCTGATCGACGACCAGGGCATGCTCTGCGGGCGCGGCGCGGCGGACATGAAAGGCAGCCTGGCGTCGATGATCGTCGCCGTCGAGCGCTTCGTCGCCGACCACCCGGAGCACAAGGGTGCCATCGCCTTCCTCATCACCAGCGACGAGGAAGGCCCGGCCCACCACGGCACCAAGGCGGTGGTCGAACGCCTCGCCGCACGCGGCGAGCGCCTGGACTGGTGCATCGTCGGCGAACCGTCGAGCACCAGCCTGGTCGGCGACGTGGTGAAGAACGGCCGCCGCGGCTCCCTCGGCGCCAAGCTGACCATCCGCGGCGTACAGGGCCATGTGGCCTACCCGCACCTGGCGAAGAACCCGATCCACCTGGCCGCCCCGGCGCTGGCCGAACTGGCGGCGGAACACTGGGACGACGGCAATGCCTTCTTCCCGCCGACCAGCTTCCAGGTTTCCAACCTGAACTCCGGCACCGGCGCCACCAACGTCATCCCCGGCGAACTGACCGCGCTGTTCAACTTCCGCTTCTCCACCGAATCCACCGTCGAAGGCCTGCAGAAACGCGTCGAGGCGATCCTCGACAAGCACGGCCTGGACTGGCACGTCGAATGGGCGCTGTCCGGCCTGCCGTTCCTCACCGAGCCGGGCGAACTGCTCGATGCGGTGGCCGCCAGCATCAGGGCGGTCACCGGTCGCGAGACCCAGCCCTCGACCAGCGGCGGCACCTCCGACGGACGCTTCATCGCCACCATGGGCACCCAGGTGGTCGAACTCGGCCCGGTCAACGCCACCATCCACCAGGTCAACGAGCGGGTCCTGGCCAGCGACCTGGAACTGCTCACCGAAATCTACTACCAGACCCTGGTGAGGCTGCTCGCCTGA |
| Protein Properties |
| Protein Residues: |
383 |
| Protein Molecular Weight: |
41.1 kDa |
| Protein Theoretical pI: |
5.01 |
| Hydropathicity (GRAVY score): |
-0.033 |
| Charge at pH 7 (predicted): |
-14.01 |
| Protein Sequence: |
>PA1162
MTASSPSLSPTLELACELIRRPSVTPLDADCQALMMRRLEAAGFALEPMRIEEVDNFWARRGGDGPVLCFAGHTDVVPTGPLQAWQHQPFDALIDDQGMLCGRGAADMKGSLASMIVAVERFVADHPEHKGAIAFLITSDEEGPAHHGTKAVVERLAARGERLDWCIVGEPSSTSLVGDVVKNGRRGSLGAKLTIRGVQGHVAYPHLAKNPIHLAAPALAELAAEHWDDGNAFFPPTSFQVSNLNSGTGATNVIPGELTALFNFRFSTESTVEGLQKRVEAILDKHGLDWHVEWALSGLPFLTEPGELLDAVAASIRAVTGRETQPSTSGGTSDGRFIATMGTQVVELGPVNATIHQVNERVLASDLELLTEIYYQTLVRLLA |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA1162 and its homologs
|
