Dihydroneopterin aldolase (PA0582)

Identification
Name: Dihydroneopterin aldolase
Synonyms:
  • DHNA
Gene Name: folB
Enzyme Class:
Biological Properties
General Function: Involved in dihydroneopterin aldolase activity
Specific Function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin at appreciable velocity
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb ↔ Thumb+Thumb
7,8-Dihydroneopterin ↔ 6-Hydroxymethyl dihydropterin + Glycolaldehyde
ReactionCard
SMPDB Reactions:
7,8-Dihydroneopterin+Thumb → Thumb+Thumb
7,8-Dihydroneopterin + 7,8-Dihydroneopterin → Glycolaldehyde + 6-Hydroxymethyl dihydropterin
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb ↔ Thumb+Thumb
7,8-Dihydroneopterin ↔ 6-Hydroxymethyl dihydropterin + Glycolaldehyde
ReactionCard
Thumb ↔ Thumb
7,8-Dihydroneopterin ↔ 7,8-Dihydroneopterin
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0018802-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridineMetaboCard
PAMDB0015906-Hydroxymethyl dihydropterinMetaboCard
PAMDB0004547,8-DihydroneopterinMetaboCard
PAMDB000444GlycolaldehydeMetaboCard
GO Classification:
Function
aldehyde-lyase activity
carbon-carbon lyase activity
catalytic activity
dihydroneopterin aldolase activity
lyase activity
Process
cellular aromatic compound metabolic process
cellular metabolic process
folic acid and derivative metabolic process
metabolic process
Gene Properties
Locus tag: PA0582
Strand: +
Entrez Gene ID: 880775
Accession: NP_249273.1
GI: 15595779
Sequence start: 641073
Sequence End: 641426
Sequence Length: 353
Gene Sequence: 
>PA0582
GTGGACAGAGTTTTTATCGAAGGCTTGGAGGTCGATACCGTCATCGGCGTGTACGACTGGGAGCGCGGCATCCGTCAGTGCCTGCGCCTGGACCTGACCCTGGGCTGGGACAACCGTCCGGCCGCCGCGGGCGACGATCTCGCCCTGGCGCTGGACTATGCCGCGTTGTCCGAGCGGGTGCAGGAATTCGCCCGGGAATCGCATTTCCAGTTGGTGGAAACCTTCGCCGAGCGCCTCGCCGAGGTACTGATGGGCGAGCGCGGCATTCCCTGGCTGCGCATCCGCGTGACCAAGCCCGGCGCGGTGCCGGCGGCCCGTGGCGTTGGCGTGGAGATCGAACGCGGATGTCGCTGA
Protein Properties
Protein Residues: 117
Protein Molecular Weight: 13.1 kDa
Protein Theoretical pI: 4.64
Hydropathicity (GRAVY score): -0.054
Charge at pH 7 (predicted): -4.83
Protein Sequence: 
>PA0582
MDRVFIEGLEVDTVIGVYDWERGIRQCLRLDLTLGWDNRPAAAGDDLALALDYAALSERVQEFARESHFQLVETFAERLAEVLMGERGIPWLRIRVTKPGAVPAARGVGVEIERGCR
References
External Links:
Resource Link
Genome ID: PA0582
Entrez Gene ID: 880775
NCBI Protein ID: 15595779
General Reference: PaperBLAST - Find papers about PA0582 and its homologs