Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (PA0420)

Identification
Name: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
Synonyms:
  • 7,8-diamino-pelargonic acid aminotransferase
  • DAPA AT
  • DAPA aminotransferase
  • Diaminopelargonic acid synthase
Gene Name: bioA
Enzyme Class:
Biological Properties
General Function: Involved in transaminase activity
Specific Function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
8-Amino-7-oxononanoate + S-Adenosylmethionine ↔ S-Adenosyl-4-methylthio-2-oxobutanoate + 7,8-Diaminononanoate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
S-Adenosylmethionine + 8-Amino-7-oxononanoate ↔ S-Adenosyl-4-methylthio-2-oxobutanoate + 7,8-Diaminononanoate
ReactionCard
SMPDB Reactions:
Thumb+S-adenosyl-L-methionine → Thumb+7,8-Diaminononanoate+Thumb
8-Amino-7-oxononanoate + S-adenosyl-L-methionine → a sulfurated [sulfur carrier] + 7,8-Diaminononanoate + 7,8-Diaminononanoate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
8-Amino-7-oxononanoate + S-Adenosylmethionine ↔ S-Adenosyl-4-methylthio-2-oxobutanoate + 7,8-Diaminononanoate
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0009577,8-DiaminononanoateMetaboCard
PAMDB0009598-Amino-7-oxononanoateMetaboCard
PAMDB006303a sulfurated [sulfur carrier]MetaboCard
PAMDB001688S-Adenosyl-4-methylthio-2-oxobutanoateMetaboCard
PAMDB000289S-AdenosylmethionineMetaboCard
GO Classification:
Function
adenosylmethionine-8-amino-7-oxononanoate transaminase activity
binding
catalytic activity
cofactor binding
pyridoxal phosphate binding
transaminase activity
transferase activity
transferase activity, transferring nitrogenous groups
Process
biotin biosynthetic process
biotin metabolic process
metabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Properties
Locus tag: PA0420
Strand: -
Entrez Gene ID: 878017
Accession: NP_249111.1
GI: 15595617
Sequence start: 466833
Sequence End: 468236
Sequence Length: 1403
Gene Sequence: 
>PA0420
ATGGGCCTTAACGCCGACTGGATGCAGCGCGACCTGAACGTACTCTGGCATCCCTGTACCCAGATGAAAGACCACGAACGCCTGCCGGTGATCCCGATCCGCCGCGGCGAAGGCGTCTGGCTGGAGGATTTCGAAGGCAAGCGCTACATCGACGCGGTCAGTTCCTGGTGGGTCAATGTGTTCGGTCACGCCAACCCGCGCATCAACCAGCGCATCAAGGACCAGGTCGACCAGTTGGAGCACGTGATCCTCGCCGGATTCAGCCACCAGCCGGTGATCGAGCTGTCGGAGCGACTGGTGAAAATCACCCCGCCGGGGCTCGACCGGGTGTTCTACGCCGACAGCGGCTCGGCGGGCATCGAGGTCGCGCTGAAGATGAGCTACCACTTCTGGCTCAATAGCGGCAGGCCGCGCAAGAAGCGCTTCGTCACCCTGACCAACAGCTACCACGGCGAAACCATCGCGGCGATGTCGGTGGGCGACGTGGCGCTGTTCACCGAAACCTACAAGTCGCTGCTGCTGGACACCATCAAGGTGCCCAGCCCGGACTGCTTTCTGCGTCCGGACGGCATGTGCTGGGAAGAACATTCGCGGAACATGTTCGCCCACATGGAGCGCACCCTGGCCGAAGGGCACGACGAGATCGCCGCGGTCATCGTCGAACCGCTGATCCAGGGCGCCGGCGGCATGCGCATGTACCATCCGGTCTACCTCAAGCTGCTGCGCGAAGCCTGCGACCGCTATGGCGTGCACCTGATCCACGACGAGATCGCGGTGGGCTTCGGCCGCACCGGGACGATGTTCGCCTGCGAGCAGGCCGGCATCGCCCCGGATTTCCTCTGCCTGTCCAAGGCCCTCACCGGCGGCTACCTGCCGATGTCCGCGGTGCTGACCAGCGAGACCATCTACCGGGGCTTCTACGACGACTACCAGACCCTGCGCGCCTTCCTCCACTCGCACACCTATACCGGCAACCCGCTGGCCTGCGCCGCCGCCCTGGCGACCCTGGACATCTTCGAGGAAGACAAGGTGATCGAGGCCAACCGCGCGCTGTCCACCCACATGGCCAGGGCCACCGCGCACCTGGCCGACCACCCGCATGTCGCCGAGGTGCGCCAGACCGGGATGGTCCTGGCCATCGAAATGGTCCAGGACAAGGCGTCCAGGACGCCCTACCCCTGGCAGGAGCGCCGCGGCCTGAAGGTCTTCCAGCATGGCCTGGAGCGCGGCGCGCTGCTGCGCCCGCTGGGCAGCGTGGTGTATTTCCTGCCGCCCTACGTGATTACCCCGGAGCAGATCGACTTCCTCGCCGAGGTGGCCAGCGAAGGCATCGACATCGCCACCCGCGACGCGGTCAGCGTGGCGGTCAGCGACTTCCACCCGGACCACCGCGATCCGGGCTGA
Protein Properties
Protein Residues: 467
Protein Molecular Weight: 52.5 kDa
Protein Theoretical pI: 6.28
Hydropathicity (GRAVY score): -0.146
Charge at pH 7 (predicted): -8.91
Protein Sequence: 
>PA0420
MGLNADWMQRDLNVLWHPCTQMKDHERLPVIPIRRGEGVWLEDFEGKRYIDAVSSWWVNVFGHANPRINQRIKDQVDQLEHVILAGFSHQPVIELSERLVKITPPGLDRVFYADSGSAGIEVALKMSYHFWLNSGRPRKKRFVTLTNSYHGETIAAMSVGDVALFTETYKSLLLDTIKVPSPDCFLRPDGMCWEEHSRNMFAHMERTLAEGHDEIAAVIVEPLIQGAGGMRMYHPVYLKLLREACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIAPDFLCLSKALTGGYLPMSAVLTSETIYRGFYDDYQTLRAFLHSHTYTGNPLACAAALATLDIFEEDKVIEANRALSTHMARATAHLADHPHVAEVRQTGMVLAIEMVQDKASRTPYPWQERRGLKVFQHGLERGALLRPLGSVVYFLPPYVITPEQIDFLAEVASEGIDIATRDAVSVAVSDFHPDHRDPG
References
External Links:
Resource Link
Genome ID: PA0420
Entrez Gene ID: 878017
NCBI Protein ID: 15595617
General Reference: PaperBLAST - Find papers about PA0420 and its homologs