Reaction 21876

Reaction Details
Reaction: Thumb
4-methyl-2-oxopentanoate + an [apo BCAA dehydrogenase E2 protein] N6-lipoyl-L-lysine + H+ → a [apo BCAA dehydrogenase E2 protein] N6-S-[3-methylbutanoyl]dihydrolipoyl-L-lysine + CO2
Enzymes: Not Available
External Links:
ResourceLink
PseudoCyc Reaction ID:KETOISOCAPROATE-RXN
References:
  • Bowden JA, Connelly JL (1968). "Branched chain alpha-keto acid metabolism. II. Evidence for the common identity of alpha-ketoisocaproic acid and alpha-keto-beta-methyl-valeric acid dehydrogenases." J Biol Chem 243(12);3526-31. PMID: 5656388
  • Connelly JL, Danner DJ, Bowden JA (1968). "Branched chain alpha-keto acid metabolism. I. Isolation, purification, and partial characterization of bovine liver alpha-ketoisocaproic:alpha-keto-beta-methylvaleric acid dehydrogenase." J Biol Chem 243(6);1198-203. PMID: 5689906
  • Danner DJ, Lemmon SK, Besharse JC, Elsas LJ (1979). "Purification and characterization of branched chain alpha-ketoacid dehydrogenase from bovine liver mitochondria." J Biol Chem 254(12);5522-6. PMID: 447664
  • Perham RN (2000). "Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions." Annu Rev Biochem 69;961-1004. PMID: 10966480
  • Pettit FH, Yeaman SJ, Reed LJ (1978). "Purification and characterization of branched chain alpha-keto acid dehydrogenase complex of bovine kidney." Proc Natl Acad Sci U S A 75(10);4881-5. PMID: 283398