Reaction 21671

Reaction Details
Reaction: Thumb
2-keto-4-hydroxypimelate → succinate semialdehyde + pyruvate
Enzymes: Not Available
External Links:
ResourceLink
PseudoCyc Reaction ID:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN
References:
  • Rea D, Fulop V, Bugg TD, Roper DI (2007). "Structure and mechanism of HpcH: a metal ion dependent class II aldolase from the homoprotocatechuate degradation pathway of Escherichia coli." J Mol Biol 373(4);866-76. PMID: 17881002
  • Wang W, Seah SY (2005). "Purification and biochemical characterization of a pyruvate-specific class II aldolase, HpaI." Biochemistry 44(27);9447-55. PMID: 15996099
  • Wang W, Seah SY (2008). "The role of a conserved histidine residue in a pyruvate-specific Class II aldolase." FEBS Lett 582(23-24);3385-8. PMID: 18775708
  • Wang W, Baker P, Seah SY (2010). "Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: substrate specificity, kinetic mechanism, and substrate channeling." Biochemistry 49(17);3774-82. PMID: 20364820