Reaction Details
Reaction: Thumb
precorrin-8x + H+ → hydrogenobyrinate
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:5.4.1.2-RXN
References:
  • Crouzet J, Cameron B, Cauchois L, Rigault S, Rouyez MC, Blanche F, Thibaut D, Debussche L (1990). "Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid." J Bacteriol 172(10);5980-90. PMID: 2211521
  • Roessner CA, Warren MJ, Santander PJ, Atshaves BP, Ozaki S, Stolowich NJ, Iida K, Scott AI (1992). "Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis. Identification of the 11-methyl and 20-methyl transferases of corrin biosynthesis." FEBS Lett 301(1);73-8. PMID: 1451790
  • Roth JR, Lawrence JG, Rubenfield M, Kieffer-Higgins S, Church GM (1993). "Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium." J Bacteriol 175(11);3303-16. PMID: 8501034
  • Shipman LW, Li D, Roessner CA, Scott AI, Sacchettini JC (2001). "Crystal structure of precorrin-8x methyl mutase." Structure 9(7);587-96. PMID: 11470433
  • Thibaut D, Couder M, Famechon A, Debussche L, Cameron B, Crouzet J, Blanche F (1992). "The final step in the biosynthesis of hydrogenobyrinic acid is catalyzed by the cobH gene product with precorrin-8x as the substrate." J Bacteriol 174(3);1043-9. PMID: 1732194