Reaction 21591

Reaction Details
Reaction: Thumb
dTDP-α-D-glucose → dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H2O
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:DTDPGLUCDEHYDRAT-RXN
References:
  • Gilbert JM, MatsuhashiM, Strominger JL (1965). "Thymidine diphosphate 4-acetamido-4,6-dideoxyhexoses. II. Purification and properties of thymidine diphosphate D-glucose oxidoreductase." J Biol Chem 240;1305-8. PMID: 14284740
  • Gross JW, Hegeman AD, Gerratana B, Frey PA (2001). "Dehydration is catalyzed by glutamate-136 and aspartic acid-135 active site residues in Escherichia coli dTDP-glucose 4,6-dehydratase." Biochemistry 40(42);12497-504. PMID: 11601973
  • Hegeman AD, Gross JW, Frey PA (2001). "Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: identification and preliminary characterization of functional amino acid residues at the active site." Biochemistry 40(22);6598-610. PMID: 11380254
  • Melo A, Elliott WH, Glaser L (1968). "The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase." J Biol Chem 1968;243(7);1467-74. PMID: 4869560
  • Wang SF, Gabriel O (1969). "Biological mechanisms involved in the formation of deoxy sugars. V. Isolation and crystallization of thymidine diphosphate-D-glucose oxidoreductase from Escherichia coli B." J Biol Chem 1969;244(13);3430-7. PMID: 4307450