Reaction Details
Reaction: Thumb
N-acetyl-α-D-glucosamine 1-phosphate + UTP + H+ → UDP-N-acetyl-α-D-glucosamine + diphosphate
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:NAG1P-URIDYLTRANS-RXN
References:
  • Gehring AM, Lees WJ, Mindiola DJ, Walsh CT, Brown ED (1996). "Acetyltransfer precedes uridylyltransfer in the formation of UDP-N-acetylglucosamine in separable active sites of the bifunctional GlmU protein of Escherichia coli." Biochemistry 1996;35(2);579-85. PMID: 8555230
  • Mengin-Lecreulx D, van Heijenoort J (1994). "Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis." J Bacteriol 176(18);5788-95. PMID: 8083170
  • Olsen LR, Roderick SL (2001). "Structure of the Escherichia coli GlmU pyrophosphorylase and acetyltransferase active sites." Biochemistry 40(7);1913-21. PMID: 11329257
  • Pattabiraman TN, Bachhawat BK (1961). "Purification of uridine diphosphoacetylglucosamine pyrophosphorylase from sheep brain." Biochim Biophys Acta 50;129-34. PMID: 13733356
  • Peneff C, Ferrari P, Charrier V, Taburet Y, Monnier C, Zamboni V, Winter J, Harnois M, Fassy F, Bourne Y (2001). "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture." EMBO J 20(22);6191-202. PMID: 11707391
  • Strominger JL, Smith MS (1959). "Uridine diphosphoacetylglucosamine pyrophosphorylase." J Biol Chem 234(7);1822-7. PMID: 13672971
  • Wang-Gillam A, Pastuszak I, Elbein AD (1998). "A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc." J Biol Chem 273(42);27055-7. PMID: 9765219