P. aeruginosa Metabolome Database Reaction 21449

Reaction Details

Reaction:

GDP-β-L-fucose + NADP⁺ ← GDP-4-dehydro-6-deoxy-α-D-mannose + NADPH + H⁺

Enzymes:

Not Available

External Links:

Resource	Link
PseudoCyc Reaction ID:	1.1.1.271-RXN

References:

Chang S, Duerr B, Serif G (1988). "An epimerase-reductase in L-fucose synthesis." J Biol Chem 263(4);1693-7. PMID: 3338988
Mattila P, Rabina J, Hortling S, Helin J, Renkonen R (2000). "Functional expression of Escherichia coli enzymes synthesizing GDP-L-fucose from inherent GDP-D-mannose in Saccharomyces cerevisiae." Glycobiology 10(10);1041-7. PMID: 11030750
Menon S, Stahl M, Kumar R, Xu GY, Sullivan F (1999). "Stereochemical course and steady state mechanism of the reaction catalyzed by the GDP-fucose synthetase from Escherichia coli." J Biol Chem 274(38);26743-50. PMID: 10480878
Somers WS, Stahl ML, Sullivan FX (1998). "GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site." Structure 6(12);1601-12. PMID: 9862812