Reaction 21072

Reaction Details
Reaction: Thumb
homogentisate + oxygen → 4-maleyl-acetoacetate + H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:HOMOGENTISATE-12-DIOXYGENASE-RXN
References:
  • Adachi K, Iwayama Y, Tanioka H, Takeda Y (1966). "Purification and properties of homogentisate oxygenase from Pseudomonas fluorescens." Biochim Biophys Acta 118(1);88-97. PMID: 5954067
  • CRANDALL DI, HALIKIS DN (1954). "Homogentisic acid oxidase. I. Distribution in animal tissue and relation to tyrosine metabolism in rat kidney." J Biol Chem 208(2);629-38. PMID: 13174573
  • KITA H, KAMIMOTO M, SENOH S, ADACHI T, TAKEDA Y (1965). "CRYSTALLIZATION AND SOME PROPERTIES OF 3,4-DIHYDROXYPHENYLACETATE-2,3-OXYGENASE." Biochem Biophys Res Commun 18;66-70. PMID: 14265758
  • KNOX WE, EDWARDS SW (1955). "Homogentisate oxidase of liver." J Biol Chem 216(2);479-87. PMID: 13271328
  • RAVDIN RG, CRANDALL DI (1951). "The enzymatic conversion of homogentisic acid to 4-fumarylacetoacetic acid." J Biol Chem 189(1);137-49. PMID: 14832225