dihydroorotase (PA5541)

Identification
Name: dihydroorotase
Synonyms: pyrC2
Gene Name: pyrQ
Enzyme Class: Not Available
Biological Properties
General Function: pyrimidine nucleotide biosynthetic process
Specific Function: dihydroorotase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Cellular Location: Cytoplasmic
KEGG Pathways:
  • superpathway of pyrimidine ribonucleotides de novo biosynthesis PWY0-162
  • superpathway of histidine, purine, and pyrimidine biosynthesis PRPP-PWY
  • UMP biosynthesis PWY-5686
  • superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis PWY-7211
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Thumb
    (S)-dihydroorotate + H2O ← N-carbamoyl-L-aspartate + H+
    ReactionCard
    Complex Reactions: Not Available
    Transports: Not Available
    Metabolites: Not Available
    GO Classification:
    Function
    dihydroorotase activity
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
    Process
    pyrimidine nucleotide biosynthetic process
    Gene Properties
    Locus tag: PA5541
    Strand: +
    Entrez Gene ID: 878465
    Accession: NP_254228.1
    GI: 15600734
    Sequence start: 6233118
    Sequence End: 6234455
    Sequence Length: 1337
    Gene Sequence: 
    >PA5541
ATGCAAAGCCTGCTGATCCGCAATGCCCGGATGGTCAACGAGGGGCAGGTACGCGAAGGCGATCTGCTGGTCCGCCACGGTCGCATCGAACGCATCGCCGGCTGCCTGGAAAACTGCGGCGCCAGCCGGGAGATCGATGCCGCCGGACGCTACCTGCTGCCGGGAATGATCGACGACCAGGTGCACTTCCGCGAGCCGGGTTATCCACAGAAGGGCTCGATCGCCAGCGAATCCCGCGCCGCCGTGGCGGGCGGCATCACCAGTTTCATGGACATGCCCAATACCCGCCCGGCGACGCTGAGCCTCGAAGCGCTGGCGGAAAAGAAGCGCCTCGCCGCCGCCCATAGCGTGGCCAACTACGGTTTCCACTTCGGCGTCAGCCGCGACAACCTCGACACCGTGGCCGCCCTCGATCCACGCGAGGTCGCCGCGGTGAAGGTGTTCATGGGCGCCTCCACCGGCGACATGCTGGTGGACGACCTGCCGACCCTGGAGCGCCTGTTCGCCAGCGTTCCGACCCTGCTGCTGAGCCATTGCGAAGACACGCCGCGGATCGAAGCCAACCTGGCGCGCTGGCGACAACGCTTCGGTGAACGTATTCCGGCAGCCGCCCACCCGCGCATTCGCGACGCCGAGGCTTGCTACCGTTCCACCGCCCTGGCGGTGGAACTGGCGCAACGACATGGCACGCTGCTGCATGTCCTGCACTTATCCACAGCGCGTGAACTGGCCCTGTTCGAGGACAAGCCGCTGTGCCAGAAACGCATCACCGCGGAAGTCTGCGTCCACCATCTGCTGTTCGACGACAGCGACTACGCCCGCCTCGGCCATCTGCTCAAGTGCAACCCGGCGATCAAGAGCCGCGAGGACCGCGACGCCCTGCGCAGGGCGCTGGCCGGCAACCGCCTGGACGTGATCGGCACCGACCACGCGCCGCACGCCTGGGCCGAGAAGCAGCAGGCTTATCCACAGGCGCCGGCCGGCCTGCCACTGGTCCAGCATGCGTTGCCGGCACTCCTGGAGCTGGTCCGCGAAGGCTGGCTGTCGCTGGCCACCCTGGTGGCGAAGACCAGCCACCGGGTCGCCGAACTGTTCGCCATCGCCGATCGCGGTTTCCTCCGCGAAGGTTACTGGGCCGACCTGGTGCTGGTCAGCGAACTGGAGCACCCGGCGCTGGCCAGCGCCATGCCGCTGCTGTCGCGCTGCAACTGGACGCCGTTCCGCCACCGGGCATTCCACCATCGGATCGATACCACCATCGTCTCCGGGCAACTCGCCTGGCACGCGGGACGCCTGTCCGACGATTGCCAGGGACTGCCCCTGCGGTTTTCCCGCTGA
    Protein Properties
    Protein Residues: 445
    Protein Molecular Weight: 49.3 kDa
    Protein Theoretical pI: 7.68
    Hydropathicity (GRAVY score): -0.162
    Charge at pH 7 (predicted): 4.79
    Protein Sequence: 
    >PA5541
MQSLLIRNARMVNEGQVREGDLLVRHGRIERIAGCLENCGASREIDAAGRYLLPGMIDDQVHFREPGYPQKGSIASESRAAVAGGITSFMDMPNTRPATLSLEALAEKKRLAAAHSVANYGFHFGVSRDNLDTVAALDPREVAAVKVFMGASTGDMLVDDLPTLERLFASVPTLLLSHCEDTPRIEANLARWRQRFGERIPAAAHPRIRDAEACYRSTALAVELAQRHGTLLHVLHLSTARELALFEDKPLCQKRITAEVCVHHLLFDDSDYARLGHLLKCNPAIKSREDRDALRRALAGNRLDVIGTDHAPHAWAEKQQAYPQAPAGLPLVQHALPALLELVREGWLSLATLVAKTSHRVAELFAIADRGFLREGYWADLVLVSELEHPALASAMPLLSRCNWTPFRHRAFHHRIDTTIVSGQLAWHAGRLSDDCQGLPLRFSR
    References
    External Links:
    Resource Link
    Genome ID: PA5541
    Entrez Gene ID: 878465
    NCBI Protein ID: 15600734
    General Reference: PaperBLAST - Find papers about PA5541 and its homologs