Beta-lactamase (PA4110)

Identification
Name: Beta-lactamase
Synonyms:
  • Cephalosporinase
Gene Name: ampC
Enzyme Class:
Biological Properties
General Function: Involved in beta-lactamase activity
Specific Function: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins
Cellular Location: Periplasm
KEGG Pathways:
KEGG Reactions:
Penicillin+Thumb ↔ Penicilloic acid
Penicillin + Water ↔ Penicilloic acid
ReactionCard
Thumb+Thumb ↔ Substituted beta-amino acid
beta-Lactam + Water ↔ Substituted beta-amino acid
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+a β-lactam → a substituted β-amino acid
Water + a β-lactam → a substituted β-amino acid
ReactionCard
Complex Reactions:
A beta-lactam+Thumb → a substituted beta-amino acid
A beta-lactam + Water → a substituted beta-amino acid
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
outer membrane-bounded periplasmic space
periplasmic space
Function
beta-lactamase activity
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Process
antibiotic catabolic process
antibiotic metabolic process
cellular metabolic process
drug metabolic process
metabolic process
Gene Properties
Locus tag: PA4110
Strand: +
Entrez Gene ID: 878149
Accession: NP_252799.1
GI: 15599305
Sequence start: 4594029
Sequence End: 4595222
Sequence Length: 1193
Gene Sequence: 
>PA4110
ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA
Protein Properties
Protein Residues: 397
Protein Molecular Weight: 43.4 kDa
Protein Theoretical pI: 8.82
Hydropathicity (GRAVY score): -0.29
Charge at pH 7 (predicted): 4.38
Protein Sequence: 
>PA4110
MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR
References
External Links:
Resource Link
Genome ID: PA4110
Entrez Gene ID: 878149
NCBI Protein ID: 15599305
General Reference: PaperBLAST - Find papers about PA4110 and its homologs