Glutamate-1-semialdehyde 2,1-aminomutase (PA3977)

Identification
Name: Glutamate-1-semialdehyde 2,1-aminomutase
Synonyms:
  • GSA
  • Glutamate-1-semialdehyde aminotransferase
  • GSA-AT
Gene Name: hemL
Enzyme Class:
Biological Properties
General Function: Involved in glutamate-1-semialdehyde 2,1-aminomutase activity
Specific Function: (S)-4-amino-5-oxopentanoate = 5- aminolevulinate
Cellular Location: Cytoplasm (Potential)
KEGG Pathways:
KEGG Reactions:
Thumb ↔ Thumb
(S)-4-Amino-5-oxopentanoate ↔ 5-Aminolevulinic acid
ReactionCard
SMPDB Reactions:
8 Thumb → 8 Thumb
8 (S)-4-Amino-5-oxopentanoate → 8 5-Aminolevulinic acid
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb ↔ Thumb
(S)-4-Amino-5-oxopentanoate ↔ 5-Aminolevulinic acid
ReactionCard
Complex Reactions:
Thumb → Thumb
(S)-4-Amino-5-oxopentanoate → 5-Aminolevulinic acid
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000866(S)-4-Amino-5-oxopentanoateMetaboCard
PAMDB0002755-Aminolevulinic acidMetaboCard
GO Classification:
Function
binding
catalytic activity
cofactor binding
glutamate-1-semialdehyde 2,1-aminomutase activity
intramolecular transferase activity
intramolecular transferase activity, transferring amino groups
isomerase activity
pyridoxal phosphate binding
transaminase activity
transferase activity
transferase activity, transferring nitrogenous groups
Process
biosynthetic process
cellular biosynthetic process
heterocycle biosynthetic process
metabolic process
tetrapyrrole biosynthetic process
Gene Properties
Locus tag: PA3977
Strand: +
Entrez Gene ID: 880859
Accession: NP_252666.1
GI: 15599172
Sequence start: 4457362
Sequence End: 4458645
Sequence Length: 1283
Gene Sequence: 
>PA3977
ATGTCCCGTTCCGAAACGCTGTTCAACAACGCCCAGAAACACATTCCCGGCGGGGTCAACTCCCCGGTGCGCGCCTTCAAGAGCGTCGGCGGCACCCCGCTGTTCTTCAAGCACGCCGAAGGCGCCTATGTACTGGACGAGGACGACAAGCGCTACGTGGACTATGTCGGCTCCTGGGGCCCGATGATCCTCGGCCACAGCCATCCGGACGTGCTCGACGCGGTGCGCCGGCAACTCGACCACGGCCTGTCCTATGGCGCGCCGACCGCGCTGGAAGTGGAAATGGCCGACCTGGTCTGCTCCATGGTGCCGTCGATGGAGATGGTGCGCATGGTCAGCTCCGGCACCGAGGCGACCATGAGCGCCATCCGCCTGGCCCGCGGCTACACCGGGCGCGACAGCATCATCAAGTTCGAAGGCTGCTACCACGGTCACTCCGACAGCCTGCTGGTGAAGGCCGGCTCCGGCGCCCTGACCTTCGGCGTGCCGAACTCCCCGGGCGTTCCGGCGGCCTTCGCCAAGCACACCCTGACCCTGCCGTTCAACGACATCGAGGCGGTGCGCAAGACCCTGGGCGAAGTCGGCAAGGAGGTCGCCTGCATCATCGTCGAGCCGGTTGCCGGCAACATGAACTGTGTGCCGCCGGCGCCGGGCTTCCTCGAAGGCCTGCGCGAAGCCTGCGACGAACACGGCGTGGTGCTGATCTTCGACGAAGTGATGACCGGCTTCCGTGTCGCCCTCGGCGGCGCCCAGGCCTACTACGGGGTCACCCCGGACCTGTCGACCTTCGGCAAGATCATCGGCGGCGGCATGCCGGTGGGCGCCTTCGGCGGCAAGCGCGAGATCATGCAGCAGATTTCCCCGCTGGGCCCGGTCTACCAGGCCGGCACGCTCTCGGGCAACCCGCTGGCAATGGCCGCCGGCCTGACCACCCTGCGCCTGATCAGCCGCCCCGGTTTCCACGACGAACTGACCGCCTACACCACGCGCATGCTCGACGGCCTGCAACAGCGCGCGGATGCCGCCGGCATCCCCTTCGTCACCACCCAGGCGGGCGGCATGTTCGGCCTGTACTTCAGCGGCGCCGACGCCATCGTCACCTTCGAGGACGTGATGGCCAGCGACGTCGAACGCTTCAAGCGCTTCTTCCACCTGATGCTCGACGGTGGCGTGTACCTTGCGCCTAGCGCCTTCGAGGCCGGCTTCACCTCCATCGCCCATGGCGACAAGGAGCTGGAAATCACGCTGAACGCCGCCGAAAAAGCCTTCGCCGCGCTGAAATGA
Protein Properties
Protein Residues: 427
Protein Molecular Weight: 45.4 kDa
Protein Theoretical pI: 5.57
Hydropathicity (GRAVY score): 0.099
Charge at pH 7 (predicted): -9.26
Protein Sequence: 
>PA3977
MSRSETLFNNAQKHIPGGVNSPVRAFKSVGGTPLFFKHAEGAYVLDEDDKRYVDYVGSWGPMILGHSHPDVLDAVRRQLDHGLSYGAPTALEVEMADLVCSMVPSMEMVRMVSSGTEATMSAIRLARGYTGRDSIIKFEGCYHGHSDSLLVKAGSGALTFGVPNSPGVPAAFAKHTLTLPFNDIEAVRKTLGEVGKEVACIIVEPVAGNMNCVPPAPGFLEGLREACDEHGVVLIFDEVMTGFRVALGGAQAYYGVTPDLSTFGKIIGGGMPVGAFGGKREIMQQISPLGPVYQAGTLSGNPLAMAAGLTTLRLISRPGFHDELTAYTTRMLDGLQQRADAAGIPFVTTQAGGMFGLYFSGADAIVTFEDVMASDVERFKRFFHLMLDGGVYLAPSAFEAGFTSIAHGDKELEITLNAAEKAFAALK
References
External Links:
Resource Link
Genome ID: PA3977
Entrez Gene ID: 880859
NCBI Protein ID: 15599172
General Reference: PaperBLAST - Find papers about PA3977 and its homologs