Identification
Name: (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Synonyms:
  • (3R)-hydroxymyristoyl ACP dehydrase
  • 17 kDa actomyosin component
Gene Name: fabZ
Enzyme Class:
Biological Properties
General Function: Involved in hydro-lyase activity
Specific Function: Involved in saturated fatty acids biosynthesis
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
(3R)-3-Hydroxybutanoyl-[acyl-carrier protein]But-2-enoyl-[acyl-carrier protein]+Thumb
(3R)-3-Hydroxybutanoyl-[acyl-carrier protein] ↔ But-2-enoyl-[acyl-carrier protein] + Water
ReactionCard
(3R)-3-Hydroxydecanoyl-[acyl-carrier protein]trans-Dec-2-enoyl-[acp]+Thumb
(3R)-3-Hydroxydecanoyl-[acyl-carrier protein] ↔ trans-Dec-2-enoyl-[acp] + Water
ReactionCard
(3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]trans-Oct-2-enoyl-[acp]+Thumb
(3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] ↔ trans-Oct-2-enoyl-[acp] + Water
ReactionCard
(3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]trans-Hexadec-2-enoyl-[acp]+Thumb
(3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] ↔ trans-Hexadec-2-enoyl-[acp] + Water
ReactionCard
(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]trans-Tetradec-2-enoyl-[acp]+Thumb
(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] ↔ trans-Tetradec-2-enoyl-[acp] + Water
ReactionCard
(R)-3-Hydroxyhexanoyl-[acp]trans-Hex-2-enoyl-[acp]+Thumb
(R)-3-Hydroxyhexanoyl-[acp] ↔ trans-Hex-2-enoyl-[acp] + Water
ReactionCard
(R)-3-Hydroxydodecanoyl-[acp]trans-Dodec-2-enoyl-[acp]+Thumb
(R)-3-Hydroxydodecanoyl-[acp] ↔ trans-Dodec-2-enoyl-[acp] + Water
ReactionCard
3-Hydroxyoctadecanoyl-[acp](2E)-Octadecenoyl-[acp]+Thumb
3-Hydroxyoctadecanoyl-[acp] ↔ (2E)-Octadecenoyl-[acp] + Water
ReactionCard
Thumbtrans-2,3-Dehydroacyl-[acyl-carrier protein]+Thumb
(3R)-3-Hydroxyacyl-[acyl-carrier protein] ↔ trans-2,3-Dehydroacyl-[acyl-carrier protein] + Water
ReactionCard
SMPDB Reactions:
3-Hydroxyglutaryl-[acp] methyl ester Thumb+Enoylglutaryl-[acp] methyl ester
3-Hydroxyglutaryl-[acp] methyl ester → Water + Enoylglutaryl-[acp] methyl ester
ReactionCard
3-Hydroxypimeloyl-[acp] methyl ester an enoylpimeloyl-[acp] methyl ester+Thumb
3-Hydroxypimeloyl-[acp] methyl ester → an enoylpimeloyl-[acp] methyl ester + Water
ReactionCard
a 3R-hydroxy cis ?7-tetradecenoyl-[acp]Thumb+ trans-?3-cis-?7-tetradecenoyl-[acp]
a 3R-hydroxy cis ?7-tetradecenoyl-[acp] → Water + trans-?3-cis-?7-tetradecenoyl-[acp]
ReactionCard
3R-hydroxy cis ?9-hexadecenoyl-[acp] Thumb+trans-?3-cis-?9-hexadecenoyl-[acp]
3R-hydroxy cis ?9-hexadecenoyl-[acp] → Water + trans-?3-cis-?9-hexadecenoyl-[acp]
ReactionCard
(R)-3-hydroxy-cis-vaccenoyl-[acp] Thumb+cis-vaccen-2-enoyl-[acp]
(R)-3-hydroxy-cis-vaccenoyl-[acp] → Water + cis-vaccen-2-enoyl-[acp]
ReactionCard
(3R)-3-hydroxyacyl-[acyl-carrier protein] Thumb+ trans-2-enoyl-[acyl-carrier protein]
(3R)-3-hydroxyacyl-[acyl-carrier protein] → Water + trans-2-enoyl-[acyl-carrier protein]
ReactionCard
(R)-3-hydroxybutanoyl-[acp]Thumb+crotonyl-[acp]
(R)-3-hydroxybutanoyl-[acp] → Water + crotonyl-[acp]
ReactionCard
(R)-3-hydroxyhexanoyl-[acp] Thumb+trans hex-2-enoyl-[acp]
(R)-3-hydroxyhexanoyl-[acp] → Water + trans hex-2-enoyl-[acp]
ReactionCard
an (R)-3-hydroxydecanoyl-[acp]?Thumb+a trans-?2-decenoyl-[acp]?
an (R)-3-hydroxydecanoyl-[acp]? → Water + a trans-?2-decenoyl-[acp]?
ReactionCard
(R)-3-hydroxydodecanoyl-[acp] Thumb+trans dodec-2-enoyl-[acp]
(R)-3-hydroxydodecanoyl-[acp] → Water + trans dodec-2-enoyl-[acp]
ReactionCard
(R)-3-hydroxypalmitoyl-[acp] Thumb+ trans hexadecenoyl-[acp]
(R)-3-hydroxypalmitoyl-[acp] → Water + trans hexadecenoyl-[acp]
ReactionCard
a 3R-hydroxyglutaryl-[acp] methyl esterThumb+Enoylglutaryl-[acp] methyl ester
a 3R-hydroxyglutaryl-[acp] methyl ester → Water + Enoylglutaryl-[acp] methyl ester
ReactionCard
(R)-3-hydroxyoctanoyl-[acp] Thumb+ trans oct-2-enoyl-[acp]
(R)-3-hydroxyoctanoyl-[acp] → Water + trans oct-2-enoyl-[acp]
ReactionCard
(3R)-3-hydroxymyristoyl-[acp] Thumb+ trans tetradec-2-enoyl-[acp]
(3R)-3-hydroxymyristoyl-[acp] → Water + trans tetradec-2-enoyl-[acp]
ReactionCard
a (3R)-hydroxy cis ?5-dodecenoyl-[acp]Thumb+trans-?3-cis-?5-dodecenoyl-[acp]
a (3R)-hydroxy cis ?5-dodecenoyl-[acp] → Water + trans-?3-cis-?5-dodecenoyl-[acp]
ReactionCard
PseudoCyc/BioCyc Reactions:
(R)-3-hydroxy-cis-dodec-5-enoyl-[acyl-carrier protein]Thumb+trans-3-cis-5-dodecenoyl-[acyl-carrier protein]
(R)-3-hydroxy-cis-dodec-5-enoyl-[acyl-carrier protein] → Water + trans-3-cis-5-dodecenoyl-[acyl-carrier protein]
ReactionCard
(R)-3-hydroxy-cis-palm-9-eoyl-[acyl-carrier protein]Thumb+trans-3-cis-9-palmitoleoyl-[acyl-carrier protein]
(R)-3-hydroxy-cis-palm-9-eoyl-[acyl-carrier protein] → Water + trans-3-cis-9-palmitoleoyl-[acyl-carrier protein]
ReactionCard
(R)-3-Hydroxydodecanoyl-[acyl-carrier protein]Thumb+trans-Dodec-2-enoyl-[acyl-carrier protein]
(R)-3-Hydroxydodecanoyl-[acyl-carrier protein] → Water + trans-Dodec-2-enoyl-[acyl-carrier protein]
ReactionCard
(3R)-3-Hydroxyacyl-[acyl-carrier protein]But-2-enoyl-[acyl-carrier protein]+Thumb
(3R)-3-Hydroxyacyl-[acyl-carrier protein] → But-2-enoyl-[acyl-carrier protein] + Water
ReactionCard
(R)-3-hydroxy-cis-myristol-7-eoyl-[acyl-carrier protein]Thumb+trans-3-cis-7-myristoleoyl-[acyl-carrier protein]
(R)-3-hydroxy-cis-myristol-7-eoyl-[acyl-carrier protein] → Water + trans-3-cis-7-myristoleoyl-[acyl-carrier protein]
ReactionCard
(R)-3-hydroxy-cis-vacc-11-enoyl-[acyl-carrier protein]Thumb+trans-3-cis-11-vacceoyl-[acyl-carrier protein]
(R)-3-hydroxy-cis-vacc-11-enoyl-[acyl-carrier protein] → Water + trans-3-cis-11-vacceoyl-[acyl-carrier protein]
ReactionCard
(R)-3-Hydroxydecanoyl-[acyl-carrier protein]Thumb+trans-Dec-2-enoyl-[acyl-carrier protein]
(R)-3-Hydroxydecanoyl-[acyl-carrier protein] → Water + trans-Dec-2-enoyl-[acyl-carrier protein]
ReactionCard
(R)-3-Hydroxyhexanoyl-[acyl-carrier protein]Thumb+trans-Hex-2-enoyl-[acyl-carrier protein]
(R)-3-Hydroxyhexanoyl-[acyl-carrier protein] → Water + trans-Hex-2-enoyl-[acyl-carrier protein]
ReactionCard
(R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]Thumb+trans-octadec-2-enoyl-[acyl-carrier protein]
(R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein] → Water + trans-octadec-2-enoyl-[acyl-carrier protein]
ReactionCard
(R)-3-Hydroxyoctanoyl-[acyl-carrier protein]Thumb+trans-Oct-2-enoyl-[acyl-carrier protein]
(R)-3-Hydroxyoctanoyl-[acyl-carrier protein] → Water + trans-Oct-2-enoyl-[acyl-carrier protein]
ReactionCard
(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]Thumb+trans-Tetradec-2-enoyl-[acyl-carrier protein]
(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] → Water + trans-Tetradec-2-enoyl-[acyl-carrier protein]
ReactionCard
R-3-hydroxypalmitoyl-[acyl-carrier protein]Thumb+trans-Hexadec-2-enoyl-[acyl-carrier protein]
R-3-hydroxypalmitoyl-[acyl-carrier protein] → Water + trans-Hexadec-2-enoyl-[acyl-carrier protein]
ReactionCard
3 -Hydroxyglutaryl-[acyl-carrier protein] methyl esterEnoylglutaryl-[acyl-carrier protein] methyl ester+Thumb
3 -Hydroxyglutaryl-[acyl-carrier protein] methyl ester → Enoylglutaryl-[acyl-carrier protein] methyl ester + Water
ReactionCard
3 -Hydroxypimeloyl-[acyl-carrier protein] methyl esterEnoylpimeloyl-[acyl-carrier protein] methyl ester+Thumb
3 -Hydroxypimeloyl-[acyl-carrier protein] methyl ester → Enoylpimeloyl-[acyl-carrier protein] methyl ester + Water
ReactionCard
(R)-3-Hydroxyhexanoyl-[acp]trans-Hex-2-enoyl-[acp]+Thumb
(R)-3-Hydroxyhexanoyl-[acp] ↔ trans-Hex-2-enoyl-[acp] + Water
ReactionCard
(R)-3-Hydroxydodecanoyl-[acp]trans-Dodec-2-enoyl-[acp]+Thumb
(R)-3-Hydroxydodecanoyl-[acp] ↔ trans-Dodec-2-enoyl-[acp] + Water
ReactionCard
(3R)-3-Hydroxybutanoyl-[acyl-carrier protein]But-2-enoyl-[acyl-carrier protein]+Thumb
(3R)-3-Hydroxybutanoyl-[acyl-carrier protein] ↔ But-2-enoyl-[acyl-carrier protein] + Water
ReactionCard
(3R)-3-Hydroxydecanoyl-[acyl-carrier protein]trans-Dec-2-enoyl-[acp]+Thumb
(3R)-3-Hydroxydecanoyl-[acyl-carrier protein] ↔ trans-Dec-2-enoyl-[acp] + Water
ReactionCard
(3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]trans-Oct-2-enoyl-[acp]+Thumb
(3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] ↔ trans-Oct-2-enoyl-[acp] + Water
ReactionCard
(3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]trans-Hexadec-2-enoyl-[acp]+Thumb
(3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] ↔ trans-Hexadec-2-enoyl-[acp] + Water
ReactionCard
(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]trans-Tetradec-2-enoyl-[acp]+Thumb
(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] ↔ trans-Tetradec-2-enoyl-[acp] + Water
ReactionCard
3-Hydroxyoctadecanoyl-[acp](2E)-Octadecenoyl-[acp]+Thumb
3-Hydroxyoctadecanoyl-[acp] ↔ (2E)-Octadecenoyl-[acp] + Water
ReactionCard
Thumbtrans-2,3-Dehydroacyl-[acyl-carrier protein]+Thumb
(3R)-3-Hydroxyacyl-[acyl-carrier protein] ↔ trans-2,3-Dehydroacyl-[acyl-carrier protein] + Water
ReactionCard
3-Hydroxyglutaryl-[acp] methyl ester Thumb+Enoylglutaryl-[acp] methyl ester
3-Hydroxyglutaryl-[acp] methyl ester → Water + Enoylglutaryl-[acp] methyl ester
ReactionCard
3-Hydroxypimeloyl-[acp] methyl ester an enoylpimeloyl-[acp] methyl ester+Thumb
3-Hydroxypimeloyl-[acp] methyl ester → an enoylpimeloyl-[acp] methyl ester + Water
ReactionCard
a 3R-hydroxy cis ?7-tetradecenoyl-[acp]Thumb+ trans-?3-cis-?7-tetradecenoyl-[acp]
a 3R-hydroxy cis ?7-tetradecenoyl-[acp] → Water + trans-?3-cis-?7-tetradecenoyl-[acp]
ReactionCard
3R-hydroxy cis ?9-hexadecenoyl-[acp] Thumb+trans-?3-cis-?9-hexadecenoyl-[acp]
3R-hydroxy cis ?9-hexadecenoyl-[acp] → Water + trans-?3-cis-?9-hexadecenoyl-[acp]
ReactionCard
(R)-3-hydroxy-cis-vaccenoyl-[acp] Thumb+cis-vaccen-2-enoyl-[acp]
(R)-3-hydroxy-cis-vaccenoyl-[acp] → Water + cis-vaccen-2-enoyl-[acp]
ReactionCard
(3R)-3-hydroxyacyl-[acyl-carrier protein] Thumb+ trans-2-enoyl-[acyl-carrier protein]
(3R)-3-hydroxyacyl-[acyl-carrier protein] → Water + trans-2-enoyl-[acyl-carrier protein]
ReactionCard
(R)-3-hydroxybutanoyl-[acp]Thumb+crotonyl-[acp]
(R)-3-hydroxybutanoyl-[acp] → Water + crotonyl-[acp]
ReactionCard
(R)-3-hydroxyhexanoyl-[acp] Thumb+trans hex-2-enoyl-[acp]
(R)-3-hydroxyhexanoyl-[acp] → Water + trans hex-2-enoyl-[acp]
ReactionCard
an (R)-3-hydroxydecanoyl-[acp]?Thumb+a trans-?2-decenoyl-[acp]?
an (R)-3-hydroxydecanoyl-[acp]? → Water + a trans-?2-decenoyl-[acp]?
ReactionCard
(R)-3-hydroxydodecanoyl-[acp] Thumb+trans dodec-2-enoyl-[acp]
(R)-3-hydroxydodecanoyl-[acp] → Water + trans dodec-2-enoyl-[acp]
ReactionCard
(R)-3-hydroxypalmitoyl-[acp] Thumb+ trans hexadecenoyl-[acp]
(R)-3-hydroxypalmitoyl-[acp] → Water + trans hexadecenoyl-[acp]
ReactionCard
a 3R-hydroxyglutaryl-[acp] methyl esterThumb+Enoylglutaryl-[acp] methyl ester
a 3R-hydroxyglutaryl-[acp] methyl ester → Water + Enoylglutaryl-[acp] methyl ester
ReactionCard
(R)-3-hydroxyoctanoyl-[acp] Thumb+ trans oct-2-enoyl-[acp]
(R)-3-hydroxyoctanoyl-[acp] → Water + trans oct-2-enoyl-[acp]
ReactionCard
(3R)-3-hydroxymyristoyl-[acp] Thumb+ trans tetradec-2-enoyl-[acp]
(3R)-3-hydroxymyristoyl-[acp] → Water + trans tetradec-2-enoyl-[acp]
ReactionCard
a (3R)-hydroxy cis ?5-dodecenoyl-[acp]Thumb+trans-?3-cis-?5-dodecenoyl-[acp]
a (3R)-hydroxy cis ?5-dodecenoyl-[acp] → Water + trans-?3-cis-?5-dodecenoyl-[acp]
ReactionCard
a (3R)-3-hydroxymyristoyl-[acp] → a trans tetradec-2-enoyl-[acp] + H2O
ReactionCard
Complex Reactions:
(R)-3-hydroxy-cis-dodec-5-enoyl-[acyl-carrier protein]Thumb+trans-3-cis-5-dodecenoyl-[acyl-carrier protein]
(R)-3-hydroxy-cis-dodec-5-enoyl-[acyl-carrier protein] → Water + trans-3-cis-5-dodecenoyl-[acyl-carrier protein]
ReactionCard
(R)-3-hydroxy-cis-palm-9-eoyl-[acyl-carrier protein]Thumb+trans-3-cis-9-palmitoleoyl-[acyl-carrier protein]
(R)-3-hydroxy-cis-palm-9-eoyl-[acyl-carrier protein] → Water + trans-3-cis-9-palmitoleoyl-[acyl-carrier protein]
ReactionCard
(R)-3-Hydroxydodecanoyl-[acyl-carrier protein]Thumb+trans-Dodec-2-enoyl-[acyl-carrier protein]
(R)-3-Hydroxydodecanoyl-[acyl-carrier protein] → Water + trans-Dodec-2-enoyl-[acyl-carrier protein]
ReactionCard
(3R)-3-Hydroxyacyl-[acyl-carrier protein]But-2-enoyl-[acyl-carrier protein]+Thumb
(3R)-3-Hydroxyacyl-[acyl-carrier protein] → But-2-enoyl-[acyl-carrier protein] + Water
ReactionCard
(R)-3-hydroxy-cis-myristol-7-eoyl-[acyl-carrier protein]Thumb+trans-3-cis-7-myristoleoyl-[acyl-carrier protein]
(R)-3-hydroxy-cis-myristol-7-eoyl-[acyl-carrier protein] → Water + trans-3-cis-7-myristoleoyl-[acyl-carrier protein]
ReactionCard
(R)-3-hydroxy-cis-vacc-11-enoyl-[acyl-carrier protein]Thumb+trans-3-cis-11-vacceoyl-[acyl-carrier protein]
(R)-3-hydroxy-cis-vacc-11-enoyl-[acyl-carrier protein] → Water + trans-3-cis-11-vacceoyl-[acyl-carrier protein]
ReactionCard
(R)-3-Hydroxydecanoyl-[acyl-carrier protein]Thumb+trans-Dec-2-enoyl-[acyl-carrier protein]
(R)-3-Hydroxydecanoyl-[acyl-carrier protein] → Water + trans-Dec-2-enoyl-[acyl-carrier protein]
ReactionCard
(R)-3-Hydroxyhexanoyl-[acyl-carrier protein]Thumb+trans-Hex-2-enoyl-[acyl-carrier protein]
(R)-3-Hydroxyhexanoyl-[acyl-carrier protein] → Water + trans-Hex-2-enoyl-[acyl-carrier protein]
ReactionCard
(R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]Thumb+trans-octadec-2-enoyl-[acyl-carrier protein]
(R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein] → Water + trans-octadec-2-enoyl-[acyl-carrier protein]
ReactionCard
(R)-3-Hydroxyoctanoyl-[acyl-carrier protein]Thumb+trans-Oct-2-enoyl-[acyl-carrier protein]
(R)-3-Hydroxyoctanoyl-[acyl-carrier protein] → Water + trans-Oct-2-enoyl-[acyl-carrier protein]
ReactionCard
(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]Thumb+trans-Tetradec-2-enoyl-[acyl-carrier protein]
(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] → Water + trans-Tetradec-2-enoyl-[acyl-carrier protein]
ReactionCard
R-3-hydroxypalmitoyl-[acyl-carrier protein]Thumb+trans-Hexadec-2-enoyl-[acyl-carrier protein]
R-3-hydroxypalmitoyl-[acyl-carrier protein] → Water + trans-Hexadec-2-enoyl-[acyl-carrier protein]
ReactionCard
3 -Hydroxyglutaryl-[acyl-carrier protein] methyl esterEnoylglutaryl-[acyl-carrier protein] methyl ester+Thumb
3 -Hydroxyglutaryl-[acyl-carrier protein] methyl ester → Enoylglutaryl-[acyl-carrier protein] methyl ester + Water
ReactionCard
3 -Hydroxypimeloyl-[acyl-carrier protein] methyl esterEnoylpimeloyl-[acyl-carrier protein] methyl ester+Thumb
3 -Hydroxypimeloyl-[acyl-carrier protein] methyl ester → Enoylpimeloyl-[acyl-carrier protein] methyl ester + Water
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
carbon-oxygen lyase activity
catalytic activity
hydro-lyase activity
lyase activity
Process
carboxylic acid metabolic process
cellular metabolic process
fatty acid biosynthetic process
fatty acid metabolic process
metabolic process
monocarboxylic acid metabolic process
organic acid metabolic process
oxoacid metabolic process
Gene Properties
Locus tag: PA3645
Strand: -
Entrez Gene ID: 880494
Accession: NP_252335.1
GI: 15598841
Sequence start: 4082958
Sequence End: 4083398
Sequence Length: 440
Gene Sequence:
>PA3645
ATGATGGACATCAACGAGATTCGCGAATACCTGCCTCATCGCTATCCTTTCCTGCTGGTGGATCGGGTGGTAGAGCTGGACATCGAGGGCAAGCGCATTCGCGCCTACAAGAATGTCAGTATCAATGAGCCGTTCTTCAACGGACATTTCCCCGAGCACCCGATCATGCCGGGCGTGCTGATCATCGAGGCGATGGCCCAGGCGGCCGGTATCCTCGGTTTCAAGATGCTCGACGTGAAGCCCGCCGACGGCACCCTTTACTACTTCGTCGGTTCGGACAAGCTGCGCTTCCGCCAGCCGGTCCTGCCGGGCGACCAACTGCAACTGCACGCCAAGTTCATCAGCGTGAAGCGCAGCATCTGGAAATTCGACTGCCACGCTACCGTCGACGACAAGCCGGTATGCTCGGCTGAAATCATCTGTGCGGAACGCAAACTATGA
Protein Properties
Protein Residues: 146
Protein Molecular Weight: 16.8 kDa
Protein Theoretical pI: 7.56
Hydropathicity (GRAVY score): -0.053
Charge at pH 7 (predicted): 1.1
Protein Sequence:
>PA3645
MMDINEIREYLPHRYPFLLVDRVVELDIEGKRIRAYKNVSINEPFFNGHFPEHPIMPGVLIIEAMAQAAGILGFKMLDVKPADGTLYYFVGSDKLRFRQPVLPGDQLQLHAKFISVKRSIWKFDCHATVDDKPVCSAEIICAERKL
References
External Links:
Resource Link
Genome ID: PA3645
Entrez Gene ID: 880494
NCBI Protein ID: 15598841
General Reference: PaperBLAST - Find papers about PA3645 and its homologs