Identification
Name: 2-oxoisovalerate dehydrogenase (alpha subunit) branched-chain alpha-keto acid decarboxylase; 3-methyl-2-oxobutanoate dehydrogenase (lipoamide)
Synonyms: Not Available
Gene Name: bkdA1
Enzyme Class: Not Available
Biological Properties
General Function: cellular amino acid metabolic process, oxoacid metabolic process, metabolic process
Specific Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Cellular Location: Cytoplasmic
KEGG Pathways:
  • 2-oxoisovalerate decarboxylation to isobutanoyl-CoA PWY-5046
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Complex Reactions: Not Available
    Transports: Not Available
    Metabolites: Not Available
    GO Classification:
    Function
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    Process
    cellular amino acid metabolic process
    oxoacid metabolic process
    metabolic process
    Gene Properties
    Locus tag: PA2247
    Strand: +
    Entrez Gene ID: 877901
    Accession: NP_250937.1
    GI: 15597443
    Sequence start: 2473213
    Sequence End: 2474445
    Sequence Length: 1232
    Gene Sequence:
    >PA2247
    ATGAGTGATTACGAGCCGTTGCGTCTGCATGTCCCGGAGCCCACCGGGCGTCCTGGCTGCAAGACCGACTTTTCCTATCTGCACCTGTCCCCCGCCGGCGAGGTACGCAAGCCGCCGGTGGATGTCGAGCCCGCCGAGACCAGCGACCTGGCCTACAGCCTGGTACGTGTGCTCGACGACGACGGCCACGCCGTCGGTCCCTGGAATCCGCAGCTCAGCAACGAACAACTGCTGCGCGGCATGCGGGCGATGCTCAAGACCCGCCTGTTCGACGCGCGCATGCTCACCGCGCAACGGCAGAAAAAGCTTTCCTTCTATATGCAATGCCTCGGCGAGGAAGCCATCGCCACCGCCCACACCCTGGCCCTGCGCGACGGCGACATGTGCTTTCCGACCTATCGCCAGCAAGGCATCCTGATCACCCGCGAATACCCGCTGGTGGACATGATCTGCCAGCTTCTCTCCAACGAGGCCGACCCGCTCAAGGGCCGCCAGCTGCCGATCATGTACTCGAGCAAGGAGGCAGGTTTCTTCTCCATCTCCGGCAACCTCGCCACCCAGTTCATCCAGGCGGTCGGCTGGGGCATGGCCTCGGCGATCAAGGGCGACACGCGCATCGCCTCGGCCTGGATCGGCGACGGCGCCACCGCCGAGTCGGACTTCCACACCGCCCTCACCTTCGCCCATGTCTACCGCGCGCCGGTAATCCTCAACGTGGTCAACAACCAGTGGGCGATCTCCACCTTCCAGGCCATCGCCGGCGGCGAAGGCACCACCTTCGCCAACCGTGGCGTGGGCTGCGGGATCGCCTCGCTGCGGGTCGACGGCAATGACTTCCTGGCGGTCTACGCCGCCTCCGAGTGGGCCGCCGAGCGCGCCCGGCGCAACCTCGGGCCGAGCCTGATCGAATGGGTCACCTACCGCGCCGGCCCGCACTCGACTTCGGACGACCCGTCCAAGTACCGCCCCGCCGACGACTGGACCAACTTCCCGCTGGGCGACCCGATCGCCCGCCTGAAGCGGCACATGATCGGCCTCGGCATCTGGTCGGAGGAACAGCACGAAGCCACCCACAAGGCCCTCGAAGCCGAAGTACTGGCCGCGCAGAAACAGGCGGAGAGCCATGGCACCCTGATCGACGGCCGGGTGCCGAGCGCCGCCAGCATGTTCGAGGACGTCTATGCAGAACTGCCGGAGCACCTGCGCCGGCAACGCCAGGAGCTCGGGGTATGA
    Protein Properties
    Protein Residues: 410
    Protein Molecular Weight: 45.3 kDa
    Protein Theoretical pI: 5.94
    Hydropathicity (GRAVY score): -0.286
    Charge at pH 7 (predicted): -7.25
    Protein Sequence:
    >PA2247
    MSDYEPLRLHVPEPTGRPGCKTDFSYLHLSPAGEVRKPPVDVEPAETSDLAYSLVRVLDDDGHAVGPWNPQLSNEQLLRGMRAMLKTRLFDARMLTAQRQKKLSFYMQCLGEEAIATAHTLALRDGDMCFPTYRQQGILITREYPLVDMICQLLSNEADPLKGRQLPIMYSSKEAGFFSISGNLATQFIQAVGWGMASAIKGDTRIASAWIGDGATAESDFHTALTFAHVYRAPVILNVVNNQWAISTFQAIAGGEGTTFANRGVGCGIASLRVDGNDFLAVYAASEWAAERARRNLGPSLIEWVTYRAGPHSTSDDPSKYRPADDWTNFPLGDPIARLKRHMIGLGIWSEEQHEATHKALEAEVLAAQKQAESHGTLIDGRVPSAASMFEDVYAELPEHLRRQRQELGV
    References
    External Links:
    Resource Link
    Genome ID: PA2247
    Entrez Gene ID: 877901
    NCBI Protein ID: 15597443
    General Reference: PaperBLAST - Find papers about PA2247 and its homologs