P. aeruginosa Metabolome Database Protein PA1252

Identification

Name:

probable L-malate dehydrogenase; NADPH-dependent delta1-piperideine-2-carboxylate/delta1-pyrroline-2-carboxylate reductase

Synonyms:

Not Available

Gene Name:

dpkA

Enzyme Class:

Not Available

Biological Properties

General Function:

metabolic process, oxidation-reduction process, 4-hydroxyproline catabolic process

Specific Function:

catalyze the NADPH-dependent reduction of such cyclic imines as Delta(1)-piperideine-2-carboxylate and Delta(1)-pyrroline-2-carboxylate to form L-pipecolate and L-proline, respectively.

Cellular Location:

Cytoplasmic

KEGG Pathways:

superpathway of glyoxylate bypass and TCA TCA-GLYOX-BYPASS
superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass GLYCOLYSIS-TCA-GLYOX-BYPASS
gluconeogenesis I GLUCONEO-PWY
glyoxylate cycle GLYOXYLATE-BYPASS
TCA cycle I (prokaryotic) TCA
anaerobic respiration ANARESP1-PWY
acetyl-CoA assimilation P22-PWY
mixed acid fermentation FERMENTATION-PWY
serine-isocitrate lyase pathway P106-PWY
L-aspartate degradation II MALATE-ASPARTATE-SHUTTLE-PWY
TCA cycle VI (obligate autotrophs) PWY-5913
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase) PWY-6969

KEGG Reactions:

Not Available

SMPDB Reactions:

Not Available

PseudoCyc/BioCyc Reactions:

(S)-malate + NAD⁺ ↔ oxaloacetate + NADH + H⁺
ReactionCard

Complex Reactions:

Not Available

Transports:

Not Available

Metabolites:

Not Available

GO Classification:

Function
oxidoreductase activity
Process
metabolic process
oxidation-reduction process
4-hydroxyproline catabolic process

Gene Properties

Locus tag:

PA1252

Strand:

Entrez Gene ID:

881290

Accession:

NP_249943.1

GI:

15596449

Sequence start:

1359590

Sequence End:

1360594

Sequence Length:

1004

Gene Sequence:

>PA1252
GTGATCCGAATGACGCTGGACGAGGTCCGCGAGCTGGCCGTGCGCATCCTGCGCCGGCACGCTTTCAGCGAAGCCCATGTACAGGCGGTGGCCGATACCCTGGTGGCGGGGGAGCGTGACGAATGCGCGTCCCACGGTATCTGGCGGTTGCTCGGCTGCATCGCCACCCTGAAGGCCGGCAAGGTATCCGCCGACGCCGAGCCGGAACTGCACGACATCGCTCCCGGCCTGCTGCGGGTCGACGCCCATGGCGGGTTCTCCCAGTGCGCATTCCGGCTGGGGCTGCCGCATCTGCTGGAGAAGGCCCGCAGCCAGGGTATCGCGGCGATGGCGGTGAACCGCTGTGTGCATTTCTCCGCGCTATGGGTTGAGGTCGAGGCACTCACCGAGGCGGGCCTGGTGGCCCTGGCGACCACGCCGAGTCATGCCTGGGTGGCGCCGGCGGGCGGACGCAAGCCGATCTTCGGCACCAACCCGATCGCCTTTGGCTGGCCGCGTCCGGACGGCCCGCCGTTCGTCTTCGACTTCGCCACCAGCGCCGTGGCGCGTGGCGAGATCCAGTTGCACGAACGCGCCGGCAAGCCGATCCCGCTGGGCTGGGGGGTGGACGAGCAGGGCGAGCCGACCACCGATGCCAGCGCCGCGTTGCGAGGCGCCATGCTTACTTTCGGCGGGCACAAGGGCTCGGCCCTGGCGGCGATGGTCGAACTGCTCGCCGGTCCGCTGATCGGCGACCTGACCAGTGCCGAGTCGCTGGCCTACGACGAGGGCAGCCGTTCTTCTCCCTACGGTGGCGAACTGCTGATCGCCATCGATCCGCGGCGCATGCTCGGCGCCTCGGCGGAGGAGCACCTGGCGCGCGCCGAGACGCTGTTCGAAGGCATCGTCGAACAGGGCGCGCGCTTGCCCTCGCAGCGACGCTTCGAAGCGCGCGAACGCAGCGCCAGGGACGGCGTGACGATTCCCGAGGCGTTGCACCGGGAGCTGCTGGCGTTGCTGGAGTGA

Protein Properties

Protein Residues:

334

Protein Molecular Weight:

35.7 kDa

Protein Theoretical pI:

5.93

Hydropathicity (GRAVY score):

0.013

Charge at pH 7 (predicted):

-7.22

Protein Sequence:

>PA1252
MIRMTLDEVRELAVRILRRHAFSEAHVQAVADTLVAGERDECASHGIWRLLGCIATLKAGKVSADAEPELHDIAPGLLRVDAHGGFSQCAFRLGLPHLLEKARSQGIAAMAVNRCVHFSALWVEVEALTEAGLVALATTPSHAWVAPAGGRKPIFGTNPIAFGWPRPDGPPFVFDFATSAVARGEIQLHERAGKPIPLGWGVDEQGEPTTDASAALRGAMLTFGGHKGSALAAMVELLAGPLIGDLTSAESLAYDEGSRSSPYGGELLIAIDPRRMLGASAEEHLARAETLFEGIVEQGARLPSQRRFEARERSARDGVTIPEALHRELLALLE

References

External Links:

Resource	Link
Genome ID:	PA1252
Entrez Gene ID:	881290
NCBI Protein ID:	15596449

General Reference:

PaperBLAST - Find papers about PA1252 and its homologs

probable L-malate dehydrogenase; NADPH-dependent delta1-piperideine-2-carboxylate/delta1-pyrroline-2-carboxylate reductase (PA1252)