Record Information
Version 1.0
Update Date 1/22/2018 11:54:54 AM
Metabolite IDPAMDB110832
Identification
Name: Zn2+
Description:Zinc is an essential element, necessary for sustaining all life.Physiologically, it exists as an ion in the body. It is estimated that 3000 of the hundreds of thousands of proteins in the human body contain zinc prosthetic groups. In addition, there are over a dozen types of cells in the human body that secrete zinc ions, and the roles of these secreted zinc signals in medicine and health are now being actively studied. Intriguingly, brain cells in the mammalian forebrain are one type of cell that secretes zinc, along with its other neuronal messenger substances. Cells in the salivary gland, prostate, immune system and intestine are other types that secrete zinc. Obtaining a sufficient zinc intake during pregnancy and in young children is a problem, especially among those who cannot afford a good and varied diet. Brain development is stunted by zinc deficiency in utero and in youth. Zinc is an activator of certain enzymes, such as carbonic anhydrase. Carbonic anhydrase is important in the transport of carbon dioxide in vertebrate blood. Even though zinc is an essential requirement for a healthy body, too much zinc can be harmful. Excessive absorption of zinc can also suppress copper and iron absorption. The free zinc ion in solution is highly toxic to plants, invertebrates, and even vertebrate fish. The Free Ion Activity Model (FIAM) is well-established in the literature, and shows that just micromolar amounts of the free ion kills some organisms.
Structure
Thumb
Synonyms:
  • Zn
  • Zinc
  • Zn+2
  • Zn++
  • zinc ion
  • Zn(II)
Chemical Formula: Zn
Average Molecular Weight: 65.38
Monoisotopic Molecular Weight: 63.9291466
InChI Key: PTFCDOFLOPIGGS-UHFFFAOYSA-N
InChI: InChI=1S/Zn/q+2
CAS number: 7440-66-6
IUPAC Name:zinc(II) cation
Traditional IUPAC Name: zinc(2+) ion
SMILES:[Zn++]
Chemical Taxonomy
Taxonomy DescriptionThis compound belongs to the class of chemical entities known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
Kingdom Chemical entities
Super ClassInorganic compounds
Class Homogeneous metal compounds
Sub ClassHomogeneous transition metal compounds
Direct Parent Homogeneous transition metal compounds
Alternative Parents Not Available
Substituents
  • Homogeneous transition metal
Molecular Framework Not Available
External Descriptors
Physical Properties
State: Solid
Charge:+2
Melting point: 419.5 °C
Experimental Properties:
PropertyValueReference
Melting Point419.5 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0.16ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations: Not Available
Reactions:
Pathways:
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-03di-9000000000-0cd08967c771fb645329View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-03di-9000000000-0cd08967c771fb645329View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-03di-9000000000-0cd08967c771fb645329View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-03di-9000000000-29976d3ebd17b2d11a4bView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-03di-9000000000-29976d3ebd17b2d11a4bView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-03di-9000000000-29976d3ebd17b2d11a4bView in MoNA
References
References:
  • Rakicioglu N, Samur G, Topcu A, Topcu AA: The effect of Ramadan on maternal nutrition and composition of breast milk. Pediatr Int. 2006 Jun;48(3):278-83. [16732795 ]
  • Cominetti C, Garrido AB Jr, Cozzolino SM: Zinc nutritional status of morbidly obese patients before and after Roux-en-Y gastric bypass: a preliminary report. Obes Surg. 2006 Apr;16(4):448-53. [16608609 ]
  • Religa D, Strozyk D, Cherny RA, Volitakis I, Haroutunian V, Winblad B, Naslund J, Bush AI: Elevated cortical zinc in Alzheimer disease. Neurology. 2006 Jul 11;67(1):69-75. [16832080 ]
  • Batista MN, Cuppari L, de Fatima Campos Pedrosa L, Almeida MG, de Almeida JB, de Medeiros AC, Canziani ME: Effect of end-stage renal disease and diabetes on zinc and copper status. Biol Trace Elem Res. 2006 Jul;112(1):1-12. [16943612 ]
  • Scheplyagina LA: Impact of the mother's zinc deficiency on the woman's and newborn's health status. J Trace Elem Med Biol. 2005;19(1):29-35. [16240669 ]
  • Mocchegiani E, Costarelli L, Giacconi R, Cipriano C, Muti E, Rink L, Malavolta M: Zinc homeostasis in aging: two elusive faces of the same "metal". Rejuvenation Res. 2006 Summer;9(2):351-4. [16706668 ]
  • de Sena KC, Arrais RF, das Gracas Almeida M, de Araujo DM, dos Santos MM, de Lima VT, de Fatima Campos Pedrosa L: Effects of zinc supplementation in patients with type 1 diabetes. Biol Trace Elem Res. 2005 Summer;105(1-3):1-9. [16034148 ]
  • Tsuruoka S, Wakaumi M, Ioka T, Yamamoto H, Ando H, Sugimoto K, Fujimura A: Angiotensin II receptor blocker-induces blunted taste sensitivity: comparison of candesartan and valsartan. Br J Clin Pharmacol. 2005 Aug;60(2):204-7. [16042674 ]
  • Arnold LE, DiSilvestro RA: Zinc in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2005 Aug;15(4):619-27. [16190793 ]
  • An WL, Pei JJ, Nishimura T, Winblad B, Cowburn RF: Zinc-induced anti-apoptotic effects in SH-SY5Y neuroblastoma cells via the extracellular signal-regulated kinase 1/2. Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):40-7. Epub 2005 Jan 8. [15857667 ]
  • Shea-Budgell M, Dojka M, Nimmo M, Lee D, Xu Z: Marginal zinc deficiency increased the susceptibility to acute lipopolysaccharide-induced liver injury in rats. Exp Biol Med (Maywood). 2006 May;231(5):553-8. [16636303 ]
  • Cutinha D, Vaja S, Treacher D, Swaminathan R: Erythrocyte zinc content in critically ill patients. Clin Chem Lab Med. 2005;43(9):930-3. [16176172 ]
  • Santarelli L, Di Lorenzo L, Valentino M, Bracci M, Rapisarda V, Cassano F, Elia G, Martino MG, Neri G, Apostoli P, Soleo L: [Reduced thymulin production during occupational exposure to lead] G Ital Med Lav Ergon. 2005 Jan-Mar;27 Suppl 1:68-72. [15915658 ]
  • Kaczmarek A, Robak-Cholubek D, Sowa I, Jakiel G: Comparison of the levels of copper, zinc and iron in cervical mucus and in blood serum of women of childbearing age. Ann Univ Mariae Curie Sklodowska [Med]. 2004;59(1):72-5. [16145958 ]
  • Kouremenou-Dona E, Dona A, Papoutsis J, Spiliopoulou C: Copper and zinc concentrations in serum of healthy Greek adults. Sci Total Environ. 2006 Apr 15;359(1-3):76-81. Epub 2005 Jun 13. [15955548 ]
  • Mankad M, Sathawara NG, Doshi H, Saiyed HN, Kumar S: Seminal plasma zinc concentration and alpha-glucosidase activity with respect to semen quality. Biol Trace Elem Res. 2006 May;110(2):97-106. [16757839 ]
  • Ishikawa Y, Kudo H, Kagawa Y, Sakamoto S: Increased plasma levels of zinc in obese adult females on a weight-loss program based on a hypocaloric balanced diet. In Vivo. 2005 Nov-Dec;19(6):1035-7. [16277018 ]
  • Skarupskiene I, Kuzminskis V, Abdrachmanovas O, Ryselis S, Smalinskiene A: [Zinc and aluminum concentrations in blood of hemodialysis patients and its impact on the frequency of infections] Medicina (Kaunas). 2005;41 Suppl 1:65-8. [15901979 ]
  • Lukaski HC: Low dietary zinc decreases erythrocyte carbonic anhydrase activities and impairs cardiorespiratory function in men during exercise. Am J Clin Nutr. 2005 May;81(5):1045-51. [15883427 ]
  • Gupta SK, Singh SP, Shukla VK: Copper, zinc, and Cu/Zn ratio in carcinoma of the gallbladder. J Surg Oncol. 2005 Sep 1;91(3):204-8. [16118778 ]
Synthesis Reference: Not Available
Material Safety Data Sheet (MSDS) Download (PDF)
External Links:
ResourceLink
CAS7440-66-6
ChEBI29105
ChemSpider29723
HMDBHMDB01303
IAF126033614
KEGGC00038
MetaboLightsMTBLC29105
PubChem32051