Zinc (PAMDB000330)

IdentificationTaxonomyPhysical PropertiesBiological PropertiesSpectraConcentrationsLinksReferencesEnzymes Transporters
Proteins (3280)
Record Information
Version 1.0
Update Date 1/22/2018 12:54:54 PM
Metabolite IDPAMDB000330
Identification
Name: Zinc
Description:Zinc is an essential element, necessary for sustaining all life. It is an essential trace element, necessary for plants, animals, and microorganisms. Zinc is found in nearly 100 specific enzymes (other sources say 300), serves as structural ions in transcription factors and is stored and transferred in metallothioneins. It is "typically the second most abundant transition metal in organisms" after iron and it is the only metal which appears in all enzyme classes. (Wikipedia)
Structure
Thumb
🔍MOLSDFPDBSMILESInChIView Structure
Synonyms:
  • Zinc
  • Zinc ion
  • Zn
  • Zn(II)
  • ZN++
  • ZN+2
  • Zn++
  • Zn+2
Chemical Formula: Zn
Average Molecular Weight: 65.409
Monoisotopic Molecular Weight: 63.929146578
InChI Key: HCHKCACWOHOZIP-UHFFFAOYSA-N
InChI:InChI=1S/Zn
CAS number: 7440-66-6
IUPAC Name:zinc(2+) ion
Traditional IUPAC Name: zinc(2+) ion
SMILES:[Zn]
Chemical Taxonomy
Taxonomy DescriptionThis compound belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
Kingdom Inorganic compounds
Super ClassHomogeneous metal compounds
Class Homogeneous transition metal compounds
Sub ClassNot Available
Direct Parent Homogeneous transition metal compounds
Alternative Parents Not Available
Substituents
  • Homogeneous transition metal
  • Acyclic compound
Molecular Framework Acyclic compounds
External Descriptors
Physical Properties
State: Solid
Charge:2
Melting point: 419.5 °C
Experimental Properties:
PropertyValueSource
Predicted Properties
PropertyValueSource
logP0.16ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations: Cytoplasm
Reactions:
Adenosine triphosphate + Water + Zinc > ADP + Hydrogen ion + Phosphate + Zinc
Adenosine triphosphate + Water + Zinc > ADP + Hydrogen ion + Phosphate + Zinc
-->-->-->-->-->-->
Pathways:
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-03di-9000000000-0cd08967c771fb645329View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-03di-9000000000-0cd08967c771fb645329View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-03di-9000000000-0cd08967c771fb645329View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-03di-9000000000-29976d3ebd17b2d11a4bView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-03di-9000000000-29976d3ebd17b2d11a4bView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-03di-9000000000-29976d3ebd17b2d11a4bView in MoNA
References
References:
  • An WL, Pei JJ, Nishimura T, Winblad B, Cowburn RF: Zinc-induced anti-apoptotic effects in SH-SY5Y neuroblastoma cells via the extracellular signal-regulated kinase 1/2. Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):40-7. Epub 2005 Jan 8. Pubmed: 15857667
  • Arnold LE, DiSilvestro RA: Zinc in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2005 Aug;15(4):619-27. Pubmed: 16190793
  • Batista MN, Cuppari L, de Fatima Campos Pedrosa L, Almeida MG, de Almeida JB, de Medeiros AC, Canziani ME: Effect of end-stage renal disease and diabetes on zinc and copper status. Biol Trace Elem Res. 2006 Jul;112(1):1-12. Pubmed: 16943612
  • Cominetti C, Garrido AB Jr, Cozzolino SM: Zinc nutritional status of morbidly obese patients before and after Roux-en-Y gastric bypass: a preliminary report. Obes Surg. 2006 Apr;16(4):448-53. Pubmed: 16608609
  • Cutinha D, Vaja S, Treacher D, Swaminathan R: Erythrocyte zinc content in critically ill patients. Clin Chem Lab Med. 2005;43(9):930-3. Pubmed: 16176172
  • de Sena KC, Arrais RF, das Gracas Almeida M, de Araujo DM, dos Santos MM, de Lima VT, de Fatima Campos Pedrosa L: Effects of zinc supplementation in patients with type 1 diabetes. Biol Trace Elem Res. 2005 Summer;105(1-3):1-9. Pubmed: 16034148
  • Gupta SK, Singh SP, Shukla VK: Copper, zinc, and Cu/Zn ratio in carcinoma of the gallbladder. J Surg Oncol. 2005 Sep 1;91(3):204-8. Pubmed: 16118778
  • Ishikawa Y, Kudo H, Kagawa Y, Sakamoto S: Increased plasma levels of zinc in obese adult females on a weight-loss program based on a hypocaloric balanced diet. In Vivo. 2005 Nov-Dec;19(6):1035-7. Pubmed: 16277018
  • Kaczmarek A, Robak-Cholubek D, Sowa I, Jakiel G: Comparison of the levels of copper, zinc and iron in cervical mucus and in blood serum of women of childbearing age. Ann Univ Mariae Curie Sklodowska [Med]. 2004;59(1):72-5. Pubmed: 16145958
  • Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. Pubmed: 22080510
  • Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. Pubmed: 21097882
  • Kouremenou-Dona E, Dona A, Papoutsis J, Spiliopoulou C: Copper and zinc concentrations in serum of healthy Greek adults. Sci Total Environ. 2006 Apr 15;359(1-3):76-81. Epub 2005 Jun 13. Pubmed: 15955548
  • Lukaski HC: Low dietary zinc decreases erythrocyte carbonic anhydrase activities and impairs cardiorespiratory function in men during exercise. Am J Clin Nutr. 2005 May;81(5):1045-51. Pubmed: 15883427
  • Mankad M, Sathawara NG, Doshi H, Saiyed HN, Kumar S: Seminal plasma zinc concentration and alpha-glucosidase activity with respect to semen quality. Biol Trace Elem Res. 2006 May;110(2):97-106. Pubmed: 16757839
  • Mocchegiani E, Costarelli L, Giacconi R, Cipriano C, Muti E, Rink L, Malavolta M: Zinc homeostasis in aging: two elusive faces of the same "metal". Rejuvenation Res. 2006 Summer;9(2):351-4. Pubmed: 16706668
  • Rakicioglu N, Samur G, Topcu A, Topcu AA: The effect of Ramadan on maternal nutrition and composition of breast milk. Pediatr Int. 2006 Jun;48(3):278-83. Pubmed: 16732795
  • Religa D, Strozyk D, Cherny RA, Volitakis I, Haroutunian V, Winblad B, Naslund J, Bush AI: Elevated cortical zinc in Alzheimer disease. Neurology. 2006 Jul 11;67(1):69-75. Pubmed: 16832080
  • Santarelli L, Di Lorenzo L, Valentino M, Bracci M, Rapisarda V, Cassano F, Elia G, Martino MG, Neri G, Apostoli P, Soleo L: [Reduced thymulin production during occupational exposure to lead] G Ital Med Lav Ergon. 2005 Jan-Mar;27 Suppl 1:68-72. Pubmed: 15915658
  • Scheplyagina LA: Impact of the mother's zinc deficiency on the woman's and newborn's health status. J Trace Elem Med Biol. 2005;19(1):29-35. Pubmed: 16240669
  • Shea-Budgell M, Dojka M, Nimmo M, Lee D, Xu Z: Marginal zinc deficiency increased the susceptibility to acute lipopolysaccharide-induced liver injury in rats. Exp Biol Med (Maywood). 2006 May;231(5):553-8. Pubmed: 16636303
  • Skarupskiene I, Kuzminskis V, Abdrachmanovas O, Ryselis S, Smalinskiene A: [Zinc and aluminum concentrations in blood of hemodialysis patients and its impact on the frequency of infections] Medicina (Kaunas). 2005;41 Suppl 1:65-8. Pubmed: 15901979
  • Tsuruoka S, Wakaumi M, Ioka T, Yamamoto H, Ando H, Sugimoto K, Fujimura A: Angiotensin II receptor blocker-induces blunted taste sensitivity: comparison of candesartan and valsartan. Br J Clin Pharmacol. 2005 Aug;60(2):204-7. Pubmed: 16042674
Synthesis Reference: Not Available
Material Safety Data Sheet (MSDS) Download (PDF)
External Links:
ResourceLink
CHEBI ID30185
HMDB IDHMDB01303
Pubchem Compound ID23994
Kegg IDC00038
ChemSpider ID29723
WikipediaZinc
BioCyc IDZN+2
EcoCyc IDZN+2
Ligand ExpoZN2

Enzymes

Protein Details
• Zinc import ATP-binding protein ZnuC
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system
Gene Name:
znuC
Locus Tag:
PA5500
Molecular weight:
29.2 kDa
Protein Details
• High-affinity zinc uptake system membrane protein znuB
General function:
Involved in ATP binding
Specific function:
Involved in the high-affinity zinc uptake transport system
Gene Name:
znuB
Locus Tag:
PA5501
Molecular weight:
27.3 kDa
Protein Details
• High-affinity zinc uptake system protein znuA
General function:
Involved in metal ion binding
Specific function:
Involved in the high-affinity zinc uptake transport system
Gene Name:
znuA
Locus Tag:
PA5498
Molecular weight:
33.6 kDa

Transporters

Protein Details
• Zinc import ATP-binding protein ZnuC
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system
Gene Name:
znuC
Locus Tag:
PA5500
Molecular weight:
29.2 kDa
Protein Details
• High-affinity zinc uptake system membrane protein znuB
General function:
Involved in ATP binding
Specific function:
Involved in the high-affinity zinc uptake transport system
Gene Name:
znuB
Locus Tag:
PA5501
Molecular weight:
27.3 kDa
Protein Details
• High-affinity zinc uptake system protein znuA
General function:
Involved in metal ion binding
Specific function:
Involved in the high-affinity zinc uptake transport system
Gene Name:
znuA
Locus Tag:
PA5498
Molecular weight:
33.6 kDa